ID IPI3_EREGS Reviewed; 518 AA.
AC Q75E14;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Pre-rRNA-processing protein IPI3;
GN Name=IPI3; OrderedLocusNames=ABL141C;
OS Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
OS Y-1056) (Yeast) (Ashbya gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; AE016815; AAS50630.1; -; Genomic_DNA.
DR RefSeq; NP_982806.1; NM_208159.1.
DR AlphaFoldDB; Q75E14; -.
DR SMR; Q75E14; -.
DR STRING; 284811.Q75E14; -.
DR EnsemblFungi; AAS50630; AAS50630; AGOS_ABL141C.
DR GeneID; 4618886; -.
DR KEGG; ago:AGOS_ABL141C; -.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_029749_4_0_1; -.
DR InParanoid; Q75E14; -.
DR OMA; IPQFKRV; -.
DR OrthoDB; 21962at2759; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR GO; GO:0120330; C:rixosome complex; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763:SF0; WD REPEAT-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR18763; WD-REPEAT PROTEIN 18; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..518
FT /note="Pre-rRNA-processing protein IPI3"
FT /id="PRO_0000308736"
FT REPEAT 73..123
FT /note="WD 1"
FT REPEAT 127..166
FT /note="WD 2"
FT REPEAT 175..220
FT /note="WD 3"
FT REPEAT 226..267
FT /note="WD 4"
SQ SEQUENCE 518 AA; 56115 MW; 0A35CDB92290E3A7 CRC64;
MDEQVIFTTA VSGTVCQVHS VGQANLRQCA ASTPNSAVLM GDKLLVAQAN KALINVYSVD
SRSKKEALEQ RLPLPEQLSC LAVVENHTGD AGVHQQLPYL LLGSTPSGKL YVWEAGSGKL
LTVKAMAHYQ AITKMQAIIN GKYVVTAGAD SRLIIWQTAS LVLEEEPKPL YVLHDHTLAI
TDFAVSNAHN GKYLNSKLYT VSEDMTVRCY QLSSQLEQPQ LLATFTFPLA LTSIALDPAD
RCLYVGTREG AFALPLFYKL DSSGATLVNL LQPGKHQIYS IVPEQAGVEV NKQELYRMGQ
LLCSKMLSCH VSLIRVSMDG SMVLLATGSG NCVVVDTYSK QPVKELAPLL APGTQTGPVS
NIITRSMTVK SDSLLQDLNL ADARATEAIK IPALAKTVFD KTGTHDIIYC APTDTLSSVL
PRALDLPQYL DMIAEEDSVF ANTPVTRSTV KVVGELAPAK AEALPASSAE AQQSADDTDA
EVARLRESLQ QLTGAYKDLR ALHEKLYEEH EKLLQTSK
//
