ID Q75JX1_DICDI Unreviewed; 725 AA.
AC Q75JX1; Q559P1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Sphingosine kinase related protein {ECO:0000313|EMBL:EAL71327.1};
GN Name=sgkC {ECO:0000313|EMBL:EAL71327.1};
GN ORFNames=DDB_G0272350 {ECO:0000313|EMBL:EAL71327.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL71327.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL71327.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71327.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL71327.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71327.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL71327.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000008; EAL71327.1; -; Genomic_DNA.
DR RefSeq; XP_645293.1; XM_640201.1.
DR AlphaFoldDB; Q75JX1; -.
DR STRING; 44689.Q75JX1; -.
DR PaxDb; 44689-DDB0220132; -.
DR GeneID; 8618459; -.
DR KEGG; ddi:DDB_G0272350; -.
DR dictyBase; DDB_G0272350; sgkC.
DR eggNOG; KOG1116; Eukaryota.
DR HOGENOM; CLU_381942_0_0_1; -.
DR InParanoid; Q75JX1; -.
DR OMA; EFCLAIV; -.
DR PhylomeDB; Q75JX1; -.
DR Reactome; R-DDI-1660661; Sphingolipid de novo biosynthesis.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.200.40; -; 2.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR PANTHER; PTHR12358:SF110; SPHINGOSINE KINASE RELATED PROTEIN; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EAL71327.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 271..407
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 645..697
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 79620 MW; 32ACD2C6B0DDE929 CRC64;
MSEVVSPSIE TTIVSSTTTT NSTTTPTTST TTTSTASPST SRFSFKNIFG KHSKKESGSD
SSQSSLNLKD KESKESKESK RKSKSYKRSQ SLENFSKTPS TSENNIQSPD NAAANTQPQT
TTIDTVPITM IAPTGSLPNM PEVLSNGISL EGNNNNNNNN NNNNSNSNNN EGSSSSTTAA
TTPLTESVSS ASSSSSTSTI TTTPSEVTPQ HSTSSLMKQS PQGADSVTTN NNRRSWSEQL
DSDKENFVND LNEQSVLSHP SFCEPSRVKR IKVANVTIIF NPMSGSKIGE KIMVEAKKYF
EVHGIKVHVI PTEYKGHAEV LCRTLDIEGI DVVCLVGGDG TIHEAVNGIM KRDPESRERF
VMACLPAGTG NSFVLELQGK LSIKHVCERV VNGLTVPIDI AKVTIVGKSK ISAECSRRKL
EYNTLKKKFA HVNLDASTLS SSQEAGRRSI QAYRQIRPDA LMEYGSTLGN QFNGSNGIDR
APSSSDLGND IIDSEQQAHN FDDNTPEPIY CFNSLHWGLG SKVNITAEKM RWMGKAVRYT
TAALLELCRG ERILARIEYE DANGEVTALE DEFCLAIVNN IQGAAKGMKM APKAKLNDGL
IDLILVKSHK TFDLMNIFTK VYDGTHTELD YVIYKQVKRF SITPFKKDKE RKKRLRKEKK
RIKAAIKAGR EHAKNPLEIL KTECNTILSE LEDQIDEEII DIDGELKGQT PFVCEMIPRS
VRVVV
//
