ID Q75XW8_TAKRU Unreviewed; 174 AA.
AC Q75XW8;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Adrenomedullin-1 {ECO:0000313|EMBL:BAD02341.1};
GN Name=ADM1 {ECO:0000313|EMBL:BAD02341.1};
GN Synonyms=adm {ECO:0000313|Ensembl:ENSTRUP00000044688.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:BAD02341.1};
RN [1] {ECO:0000313|EMBL:BAD02341.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14623291; DOI=10.1016/j.bbrc.2003.10.111;
RA Ogoshi M., Inoue K., Takei Y.;
RT "Identification of a novel adrenomedullin gene family in teleost fish.";
RL Biochem. Biophys. Res. Commun. 311:1072-1077(2003).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000044688.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000044688.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the adrenomedullin family.
CC {ECO:0000256|ARBA:ARBA00010575}.
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DR EMBL; AB120295; BAD02341.1; -; mRNA.
DR RefSeq; NP_001027753.1; NM_001032581.1.
DR STRING; 31033.ENSTRUP00000044688; -.
DR Ensembl; ENSTRUT00000044839.3; ENSTRUP00000044688.1; ENSTRUG00000017432.3.
DR GeneID; 445916; -.
DR KEGG; tru:445916; -.
DR CTD; 556502; -.
DR eggNOG; ENOG502S4SF; Eukaryota.
DR GeneTree; ENSGT00940000154380; -.
DR HOGENOM; CLU_099291_0_0_1; -.
DR OMA; QSFLYCC; -.
DR OrthoDB; 4548241at2759; -.
DR TreeFam; TF333447; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR PANTHER; PTHR23414; ADRENOMEDULLIN, ADM; 1.
DR PANTHER; PTHR23414:SF3; PRO-ADRENOMEDULLIN; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..174
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014106807"
FT DISULFID 96..101
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 174 AA; 20223 MW; 61535E41FCF88D4D CRC64;
MKLIFQSFLY CCLLATVAHC VEFDAKPQLK KRLNILLRNR LRRDLARVSV GKTEELQHFV
RPEDIRDTLL PHSSTDINIR TKRSKNLVNQ SRKNGCSLGT CTVHDLAFRL HQLGFQYKID
IAPVDKISPQ GYGRRRRSLP EQRVTLRLEQ GRLRPVWSRA ASQVHKLEAL LRQT
//
