ID RS4X_MACFU Reviewed; 263 AA.
AC Q76MY1;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Small ribosomal subunit protein eS4, X isoform {ECO:0000305};
DE AltName: Full=40S ribosomal protein S4, X isoform;
GN Name=RPS4X;
OS Macaca fuscata fuscata (Japanese macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9543;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RA Kim H.-S., Kageyama T., Takenaka O.;
RT "Molecular cloning and evolutionary analysis of the ribosomal protein S4
RT genes in the Japanese monkey.";
RL Korean J. Genet. 23:21-24(2001).
CC -!- FUNCTION: Component of the small ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. Part of the small subunit (SSU) processome, first
CC precursor of the small eukaryotic ribosomal subunit. During the
CC assembly of the SSU processome in the nucleolus, many ribosome
CC biogenesis factors, an RNA chaperone and ribosomal proteins associate
CC with the nascent pre-rRNA and work in concert to generate RNA folding,
CC modifications, rearrangements and cleavage as well as targeted
CC degradation of pre-ribosomal RNA by the RNA exosome.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBUNIT: Component of the small ribosomal subunit. Part of the small
CC subunit (SSU) processome, composed of more than 70 proteins and the RNA
CC chaperone small nucleolar RNA (snoRNA) U3. Identified in a IGF2BP1-
CC dependent mRNP granule complex containing untranslated mRNAs.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62701}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P62701}. Note=Localized in
CC cytoplasmic mRNP granules containing untranslated mRNAs.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC {ECO:0000305}.
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DR EMBL; AB024285; BAA87932.1; -; mRNA.
DR AlphaFoldDB; Q76MY1; -.
DR SMR; Q76MY1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0005840; C:ribosome; ISS:UniProtKB.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06087; KOW_RPS4; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.740; -; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR HAMAP; MF_00485; Ribosomal_eS4; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR000876; Ribosomal_eS4.
DR InterPro; IPR032277; Ribosomal_eS4_C.
DR InterPro; IPR013845; Ribosomal_eS4_central_region.
DR InterPro; IPR038237; Ribosomal_eS4_central_sf.
DR InterPro; IPR041982; Ribosomal_eS4_KOW.
DR InterPro; IPR013843; Ribosomal_eS4_N.
DR InterPro; IPR018199; Ribosomal_eS4_N_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11581; 30S/40S RIBOSOMAL PROTEIN S4; 1.
DR PANTHER; PTHR11581:SF47; 40S RIBOSOMAL PROTEIN S4, X ISOFORM; 1.
DR Pfam; PF16121; 40S_S4_C; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF00900; Ribosomal_S4e; 1.
DR Pfam; PF08071; RS4NT; 1.
DR PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR PROSITE; PS50889; S4; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Isopeptide bond; Nucleus; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62701"
FT CHAIN 2..263
FT /note="Small ribosomal subunit protein eS4, X isoform"
FT /id="PRO_0000130806"
FT DOMAIN 42..104
FT /note="S4 RNA-binding"
FT MOD_RES 233
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62702"
FT CROSSLNK 230
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62701"
SQ SEQUENCE 263 AA; 29598 MW; 87200E545A8958B0 CRC64;
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE
VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK
YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI QIDLETGKIT DFIKFDTGNL
CMVTGGANLG RIGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR
GKGIRLTIAE ERDKRLAAKQ SSG
//
