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Entry: Q77Y25_9PLVG
LinkDB: Q77Y25_9PLVG
Original site: Q77Y25_9PLVG 
ID   Q77Y25_9PLVG            Unreviewed;       214 AA.
AC   Q77Y25;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   10-FEB-2021, entry version 96.
DE   RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341};
GN   Name=vif {ECO:0000313|EMBL:AAB99970.1};
OS   Simian-Human immunodeficiency virus.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC   Primate lentivirus group; unclassified Primate lentivirus group.
OX   NCBI_TaxID=57667 {ECO:0000313|EMBL:AAB99970.1, ECO:0000313|Proteomes:UP000157732};
RN   [1] {ECO:0000313|EMBL:AAB99970.1, ECO:0000313|Proteomes:UP000157732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SHIV-4 {ECO:0000313|EMBL:AAB99970.1};
RX   PubMed=1613662;
RA   Li J., Lord C.I., Haseltine W., Letvin N.L., Sodroski J.;
RT   "Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that
RT   expresses the HIV-1 envelope glycoproteins.";
RL   J. Acquir. Immune Defic. Syndr. 5:639-646(1992).
RN   [2] {ECO:0000313|EMBL:AAB99960.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-89.6 {ECO:0000313|EMBL:AAB99960.1};
RX   PubMed=8627800;
RA   Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P.,
RA   Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G.,
RA   Sodroski J., Letvin N.L.;
RT   "An env gene derived from a primary human immunodeficiency virus type 1
RT   isolate confers high in vivo replicative capacity to a chimeric
RT   simian/human immunodeficiency virus in rhesus monkeys.";
RL   J. Virol. 70:3198-3206(1996).
RN   [3] {ECO:0000313|EMBL:AAC57421.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-89.6P {ECO:0000313|EMBL:AAC57421.1};
RX   PubMed=9151808;
RA   Karlsson G.B., Halloran M., Li J., Park I.W., Gomila R., Reimann K.A.,
RA   Axthelm M.K., Iliff S.A., Letvin N.L., Sodroski J.;
RT   "Characterization of molecularly cloned simian-human immunodeficiency
RT   viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.";
RL   J. Virol. 71:4218-4225(1997).
RN   [4] {ECO:0000313|EMBL:AAB99970.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-4 {ECO:0000313|EMBL:AAB99970.1}, and SHIV-89.6
RC   {ECO:0000313|EMBL:AAB99960.1};
RA   Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P.,
RA   Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G.,
RA   Sodroski J., Letvin N.L.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAD12136.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9882298;
RA   Cayabyab M., Karlsson G.B., Etemad-Moghadam B.A., Hofmann W., Steenbeke T.,
RA   Halloran M., Fanton J.W., Axthelm M.K., Letvin N.L., Sodroski J.G.;
RT   "Changes in human immunodeficiency virus type 1 envelope glycoproteins
RT   responsible for the pathogenicity of a multiply passaged simian-human
RT   immunodeficiency virus (SHIV-HXBc2).";
RL   J. Virol. 73:976-984(1999).
RN   [6] {ECO:0000313|EMBL:AAL55640.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-C2/1 {ECO:0000313|EMBL:AAL55640.1};
RA   Sakai K., Shinohara K., Takahashi E., Ami Y., Sasaki Y., Suzaki Y.,
RA   Nakasone T., Honda M.;
RT   "Comparative genetic analysis of simian/human immunodeficiency viruses
RT   (SHIVs) with pathogenic property.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AEM54753.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15113931; DOI=10.1128/JVI.78.10.5513-5519.2004;
RA   Sadjadpour R., Theodore T.S., Igarashi T., Donau O.K., Plishka R.J.,
RA   Buckler-White A., Martin M.A.;
RT   "Induction of disease by a molecularly cloned highly pathogenic simian
RT   immunodeficiency virus/human immunodeficiency virus chimera is
RT   multigenic.";
RL   J. Virol. 78:5513-5519(2004).
RN   [8] {ECO:0000313|EMBL:AAL55640.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-C2/1 {ECO:0000313|EMBL:AAL55640.1};
RX   PubMed=16603534; DOI=10.1099/vir.0.81307-0;
RA   Miyake A., Ibuki K., Enose Y., Suzuki H., Horiuchi R., Motohara M.,
RA   Saito N., Nakasone T., Honda M., Watanabe T., Miura T., Hayami M.;
RT   "Rapid dissemination of a pathogenic simian/human immunodeficiency virus to
RT   systemic organs and active replication in lymphoid tissues following
RT   intrarectal infection.";
RL   J. Gen. Virol. 87:1311-1320(2006).
RN   [9] {ECO:0000313|EMBL:ABS11163.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-89.6Pcy243 {ECO:0000313|EMBL:ABS11163.1};
RX   PubMed=18080858; DOI=10.1007/s00705-007-0009-2;
RA   Borsetti A., Baroncelli S., Maggiorella M.T., Bellino S., Moretti S.,
RA   Sernicola L., Belli R., Ridolfi B., Farcomeni S., Negri D.R., Cafaro A.,
RA   Ensoli B., Titti F.;
RT   "Viral outcome of simian-human immunodeficiency virus SHIV-89.6P adapted to
RT   cynomolgus monkeys.";
RL   Arch. Virol. 153:463-472(2008).
RN   [10] {ECO:0000313|EMBL:AEM54723.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20147396; DOI=10.1128/JVI.02279-09;
RA   Nishimura Y., Shingai M., Willey R., Sadjadpour R., Lee W.R., Brown C.R.,
RA   Brenchley J.M., Buckler-White A., Petros R., Eckhaus M., Hoffman V.,
RA   Igarashi T., Martin M.A.;
RT   "Generation of the pathogenic R5-tropic simian/human immunodeficiency virus
RT   SHIVAD8 by serial passaging in rhesus macaques.";
RL   J. Virol. 84:4769-4781(2010).
RN   [11] {ECO:0000313|EMBL:AEM54723.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Nishimura Y., Shingai M., Willey R., Sadjadpour R., Lee W.R., Brown C.R.,
RA   Brenchley J.M., Buckler-White A., Petros R., Eckhaus M., Hoffman V.,
RA   Igarashi T., Martin M.A.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AEM54753.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sadjadpour R., Theodore T.S., Igarashi T., Donau O.K., Plishka R.J.,
RA   Buckler-White A., Martin M.A.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:QHI08128.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AD8_EO {ECO:0000313|EMBL:QHI08128.1};
RX   PubMed=23129652;
RA   Shingai M., Donau O.K., Schmidt S.D., Gautam R., Plishka R.J.,
RA   Buckler-White A., Sadjadpour R., Lee W.R., LaBranche C.C., Montefiori D.C.,
RA   Mascola J.R., Nishimura Y., Martin M.A.;
RT   "Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate
RT   cross-reactive antibodies that neutralize multiple HIV-1 strains.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:19769-19774(2012).
RN   [14] {ECO:0000313|EMBL:APS90961.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Foulke J.S.Jr., DeVico A., Reitz M.;
RT   "Clade B T/F SHIV pSF257.2.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:AWH56855.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-E1p1d203 {ECO:0000313|EMBL:AWH56855.1}, SHIV-E1p2d14
RC   {ECO:0000313|EMBL:AWH56864.1}, SHIV-E1p2d57
RC   {ECO:0000313|EMBL:AWH56873.1}, and SHIV-E1p5
RC   {ECO:0000313|EMBL:AWH56882.1};
RA   Go L.Y., Mitchell J.A.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:QLK12266.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E19.2A04 {ECO:0000313|EMBL:QLK12517.1}, E19.2A10
RC   {ECO:0000313|EMBL:QLK12461.1}, E19.2B08 {ECO:0000313|EMBL:QLK12441.1},
RC   E19.2B11 {ECO:0000313|EMBL:QLK12507.1}, E19.2C09
RC   {ECO:0000313|EMBL:QLK12502.1}, E19.2C11 {ECO:0000313|EMBL:QLK12431.1},
RC   E19.2D04 {ECO:0000313|EMBL:QLK12421.1}, E19.2D05
RC   {ECO:0000313|EMBL:QLK12411.1}, E20dB01 {ECO:0000313|EMBL:QLK12266.1},
RC   E21.2G06 {ECO:0000313|EMBL:QLK12351.1}, and E21F01
RC   {ECO:0000313|EMBL:QLK12371.1};
RX   PubMed=31295427;
RA   Bender A.M., Simonetti F.R., Kumar M.R., Fray E.J., Bruner K.M.,
RA   Timmons A.E., Tai K.Y., Jenike K.M., Antar A.A.R., Liu P.T., Ho Y.C.,
RA   Raugi D.N., Seydi M., Gottlieb G.S., Okoye A.A., Del Prete G.Q.,
RA   Picker L.J., Mankowski J.L., Lifson J.D., Siliciano J.D., Laird G.M.,
RA   Barouch D.H., Clements J.E., Siliciano R.F.;
RT   "The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and
RT   HIV-2 Infections.";
RL   Cell Host Microbe 26:73-85(2019).
RN   [17] {ECO:0000313|EMBL:QBK15006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-KNH1144p1 {ECO:0000313|EMBL:QBK15006.1}, SHIV-KNH1144p2
RC   {ECO:0000313|EMBL:QBK15016.1}, and SHIV-KNH1144p4
RC   {ECO:0000313|EMBL:QBK15026.1};
RX   PubMed=30760566;
RA   Zhou M., Humbert M., Mukhtar M.M., Scinto H.B., Vyas H.K., Lakhashe S.K.,
RA   Byrareddy S.N., Maurer G., Thorat S., Owuor J., Lai Z., Chen Y.,
RA   Griffiths A., Chenine A.L., Gumber S., Villinger F., Montefiori D.,
RA   Ruprecht R.M.;
RT   "Adaptation of an R5 Simian-human Immunodeficiency Virus Encoding an HIV
RT   Clade A Envelope With or Without Ablation of Adaptive Host Immunity:
RT   Differential Selection of Viral Mutants.";
RL   J. Virol. 0:0-0(2019).
RN   [18] {ECO:0000313|EMBL:QLK12266.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E19.2A04 {ECO:0000313|EMBL:QLK12517.1}, E19.2A10
RC   {ECO:0000313|EMBL:QLK12461.1}, E19.2B08 {ECO:0000313|EMBL:QLK12441.1},
RC   E19.2B11 {ECO:0000313|EMBL:QLK12507.1}, E19.2C09
RC   {ECO:0000313|EMBL:QLK12502.1}, E19.2C11 {ECO:0000313|EMBL:QLK12431.1},
RC   E19.2D04 {ECO:0000313|EMBL:QLK12421.1}, E19.2D05
RC   {ECO:0000313|EMBL:QLK12411.1}, E20dB01 {ECO:0000313|EMBL:QLK12266.1},
RC   E21.2G06 {ECO:0000313|EMBL:QLK12351.1}, and E21F01
RC   {ECO:0000313|EMBL:QLK12371.1};
RA   Bender A., Siliciano R.;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:QHI08128.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AD8_EO {ECO:0000313|EMBL:QHI08128.1};
RA   Sadjadpour R.;
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501,
CC       ECO:0000256|RuleBase:RU003341}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|RuleBase:RU003341}. Host
CC       cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion
CC       {ECO:0000256|RuleBase:RU003341}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}. Note=In the cytoplasm, seems to
CC       colocalize with intermediate filament vimentin. A fraction is
CC       associated with the cytoplasmic side of cellular membranes, presumably
CC       via the interaction with Pr55Gag precursor.
CC       {ECO:0000256|RuleBase:RU003341}.
CC   -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein family.
CC       {ECO:0000256|ARBA:ARBA00006372, ECO:0000256|RuleBase:RU003341}.
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DR   EMBL; AF038398; AAB99960.1; -; Other_DNA.
DR   EMBL; AF038399; AAB99970.1; -; Other_DNA.
DR   EMBL; U89134; AAC57421.1; -; Other_DNA.
DR   EMBL; AF041850; AAD12136.1; -; Other_DNA.
DR   EMBL; AF217181; AAL55640.1; -; Other_RNA.
DR   EMBL; EF672090; ABS11163.1; -; Other_RNA.
DR   EMBL; JN560959; AEM54723.1; -; Other_DNA.
DR   EMBL; JN560960; AEM54733.1; -; Other_DNA.
DR   EMBL; JN560961; AEM54743.1; -; Other_DNA.
DR   EMBL; JN560962; AEM54753.1; -; Other_DNA.
DR   EMBL; JN560963; AEM54763.1; -; Other_DNA.
DR   EMBL; KU521530; APS90961.1; -; Other_DNA.
DR   EMBL; MH169603; AWH56855.1; -; Other_DNA.
DR   EMBL; MH169604; AWH56864.1; -; Other_DNA.
DR   EMBL; MH169605; AWH56873.1; -; Other_DNA.
DR   EMBL; MH169606; AWH56882.1; -; Other_DNA.
DR   EMBL; MK573511; QBK15006.1; -; Other_DNA.
DR   EMBL; MK573512; QBK15016.1; -; Other_DNA.
DR   EMBL; MK573513; QBK15026.1; -; Other_DNA.
DR   EMBL; MN816822; QHI08128.1; -; Other_DNA.
DR   EMBL; MK686153; QLK12266.1; -; Other_DNA.
DR   EMBL; MK686121; QLK12351.1; -; Other_DNA.
DR   EMBL; MK686135; QLK12371.1; -; Other_DNA.
DR   EMBL; MK686167; QLK12411.1; -; Other_DNA.
DR   EMBL; MK686168; QLK12421.1; -; Other_DNA.
DR   EMBL; MK686171; QLK12431.1; -; Other_DNA.
DR   EMBL; MK686185; QLK12441.1; -; Other_DNA.
DR   EMBL; MK686192; QLK12461.1; -; Other_DNA.
DR   EMBL; MK686172; QLK12502.1; -; Other_DNA.
DR   EMBL; MK686183; QLK12507.1; -; Other_DNA.
DR   EMBL; MK686196; QLK12517.1; -; Other_DNA.
DR   Proteomes; UP000157732; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR000475; Vif.
DR   Pfam; PF00559; Vif; 1.
DR   PRINTS; PR00349; VIRIONINFFCT.
PE   3: Inferred from homology;
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Reference proteome {ECO:0000313|Proteomes:UP000157732};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   REGION          179..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..194
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  25267 MW;  1C9C81F90D6DE17C CRC64;
     MEEEKRWIAV PTWRIPERLE RWHSLIKYLK YKTKDLQKVC YVPHFKVGWA WWTCSRVIFP
     LQEGSHLEVQ GYWHLTPEKG WLSTYAVRIT WYSKNFWTDV TPNYADILLH STYFPCFTAG
     EVRRAIRGEQ LLSCCRFPRA HKYQVPSLQY LALKVVSDVR SQGENPTWKQ WRRDNRRGLR
     MAKQNSRGDK QRGGKPPTKG ANFPGLAKVL GILA
//
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