ID Q7AKJ7_STRCO Unreviewed; 230 AA.
AC Q7AKJ7; Q7B0B2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=DmdR1 protein {ECO:0000313|EMBL:CAC28070.1};
DE SubName: Full=Iron repressor {ECO:0000313|EMBL:CAB95905.1};
GN Name=desR {ECO:0000313|EMBL:CAB95905.1};
GN Synonyms=dmdR1 {ECO:0000313|EMBL:CAC28070.1};
GN OrderedLocusNames=SCO4394 {ECO:0000313|EMBL:CAB95905.1};
GN ORFNames=SCD10.26 {ECO:0000313|EMBL:CAB95905.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB95905.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC28070.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC28070.1};
RA Flores Delgado F.J.;
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAC28070.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A3 {ECO:0000313|EMBL:CAC28070.1};
RA Flores F.J.;
RT "Cloning and analysis of dmdR genes.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAB95905.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3 {ECO:0000313|EMBL:CAB95905.1}, and ATCC BAA-471 / A3(2) /
RC M145 {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
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DR EMBL; AL939119; CAB95905.1; -; Genomic_DNA.
DR EMBL; AJ271797; CAC28070.1; -; Genomic_DNA.
DR RefSeq; NP_628563.1; NC_003888.3.
DR RefSeq; WP_003974588.1; NZ_VNID01000017.1.
DR AlphaFoldDB; Q7AKJ7; -.
DR STRING; 100226.gene:17762039; -.
DR PaxDb; 100226-SCO4394; -.
DR PATRIC; fig|100226.15.peg.4462; -.
DR eggNOG; COG1321; Bacteria.
DR HOGENOM; CLU_069532_0_0_11; -.
DR OrthoDB; 3208141at2; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR Pfam; PF04023; FeoA; 1.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..65
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
SQ SEQUENCE 230 AA; 25191 MW; D9D6F9AEBA4A17A6 CRC64;
MSGLIDTTEM YLRTILELEE EGVVPMRARI AERLDQSGPT VSQTVARMER DGLVSVAADR
HLELTDEGRR LATRVMRKHR LAECLLVDVI GLEWEQVHAE ACRWEHVMSE AVERRVLELL
RHPTESPYGN PIPGLEELGE TDGADPFLDE GMVSLADLDP GQEGKTVVVR RIGEPIQTDA
QLMYTLRRAG VQPGSVVSVT ESAGGVLVGS GGEAAELEAD TASHVFVAKR
//
