ID Q7CPM2_SALTY Unreviewed; 324 AA.
AC Q7CPM2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:AAL22245.1};
GN Name=yhdH {ECO:0000313|EMBL:AAL22245.1};
GN OrderedLocusNames=STM3376 {ECO:0000313|EMBL:AAL22245.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL22245.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL22245.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2] {ECO:0007829|PDB:3NX4}
RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH NADP(+).
RA Anderson S.M., Wawrzak Z., Peterson S., Onopriyenko O., Skarina T.,
RA Anderson W.F., Savchenko A.;
RT "Crystal structure of the yhdH oxidoreductase from Salmonella enterica in
RT complex with NADP.";
RL Submitted (JUL-2010) to the PDB data bank.
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DR EMBL; AE006468; AAL22245.1; -; Genomic_DNA.
DR RefSeq; NP_462286.1; NC_003197.2.
DR RefSeq; WP_001148246.1; NC_003197.2.
DR PDB; 3NX4; X-ray; 1.90 A; A/B=1-324.
DR PDBsum; 3NX4; -.
DR AlphaFoldDB; Q7CPM2; -.
DR SMR; Q7CPM2; -.
DR STRING; 99287.STM3376; -.
DR PaxDb; 99287-STM3376; -.
DR GeneID; 1254899; -.
DR KEGG; stm:STM3376; -.
DR PATRIC; fig|99287.12.peg.3577; -.
DR HOGENOM; CLU_026673_26_3_6; -.
DR OMA; VRSFPMV; -.
DR PhylomeDB; Q7CPM2; -.
DR BioCyc; SENT99287:STM3376-MONOMER; -.
DR EvolutionaryTrace; Q7CPM2; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0043957; F:acryloyl-CoA reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd08288; MDR_yhdh; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR014188; Acrylyl-CoA_reductase_AcuI.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR02823; oxido_YhdH; 1.
DR PANTHER; PTHR43677:SF1; ACRYLYL-COA REDUCTASE ACUI-RELATED; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3NX4};
KW Nucleotide-binding {ECO:0007829|PDB:3NX4};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014}.
FT DOMAIN 12..321
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT BINDING 41
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 156
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 158
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 159
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 178
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 179
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 180
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 198
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 240
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 242
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 256
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 265
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 267
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
FT BINDING 313
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:3NX4"
SQ SEQUENCE 324 AA; 34387 MW; 5E55B285C1F8D340 CRC64;
MQALILEQQD GKTLASVQHL EESQLPAGDV TVDVHWSSLN YKDALAITGK GKIIRHFPMI
PGIDFAGTVH ASEDPRFHAG QEVLLTGWGV GENHWGGLAE RARVKGDWLV ALPAGLSSRN
AMIIGTAGFT AMLCVMALED AGIRPQDGEV VVTGASGGVG STAVALLHKL GYQVAAVSGR
ESTHGYLKSL GANRILSRDE FAESRPLEKQ LWAGAIDTVG DKVLAKVLAQ MNYGGCVAAC
GLAGGFALPT TVMPFILRNV RLQGVDSVMT PPARRAEAWA RLVKDLPESF YAQAATEITL
ADAPKFADAI INNQVQGRTL VKIK
//
