ID Q7CQU0_SALTY Unreviewed; 285 AA.
AC Q7CQU0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Formate transporter {ECO:0000313|EMBL:AAL19908.1};
GN Name=focA {ECO:0000313|EMBL:AAL19908.1};
GN OrderedLocusNames=STM0974 {ECO:0000313|EMBL:AAL19908.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL19908.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL19908.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2] {ECO:0007829|PDB:3Q7K}
RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS).
RX PubMed=21493860; DOI=10.1126/science.1199098;
RA Lu W., Du J., Wacker T., Gerbig-Smentek E., Andrade S.L., Einsle O.;
RT "pH-dependent gating in a FocA formate channel.";
RL Science 332:352-354(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=formate(in) = formate(out); Xref=Rhea:RHEA:29679,
CC ChEBI:CHEBI:15740; Evidence={ECO:0000256|ARBA:ARBA00035914};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FNT transporter (TC 2.A.44) family.
CC {ECO:0000256|ARBA:ARBA00006470}.
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DR EMBL; AE006468; AAL19908.1; -; Genomic_DNA.
DR RefSeq; NP_459949.1; NC_003197.2.
DR RefSeq; WP_000642539.1; NC_003197.2.
DR PDB; 3Q7K; X-ray; 2.80 A; A/B/C/D/E/G/H/I/J/K=1-285.
DR PDBsum; 3Q7K; -.
DR AlphaFoldDB; Q7CQU0; -.
DR SMR; Q7CQU0; -.
DR STRING; 99287.STM0974; -.
DR PaxDb; 99287-STM0974; -.
DR GeneID; 1252492; -.
DR KEGG; stm:STM0974; -.
DR PATRIC; fig|99287.12.peg.1027; -.
DR HOGENOM; CLU_036896_3_0_6; -.
DR PhylomeDB; Q7CQU0; -.
DR BioCyc; SENT99287:STM0974-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015724; P:formate transport; IBA:GO_Central.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000292; For/NO2_transpt.
DR InterPro; IPR024002; For/NO2_transpt_CS.
DR InterPro; IPR023999; Formate_transptr_FocA.
DR NCBIfam; TIGR00790; fnt; 1.
DR NCBIfam; TIGR04060; formate_focA; 1.
DR PANTHER; PTHR30520:SF10; FORMATE TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR30520; FORMATE TRANSPORTER-RELATED; 1.
DR Pfam; PF01226; Form_Nir_trans; 1.
DR PROSITE; PS01005; FORMATE_NITRITE_TP_1; 1.
DR PROSITE; PS01006; FORMATE_NITRITE_TP_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3Q7K};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 285 AA; 30969 MW; C622BA4FEF32A11D CRC64;
MKADNPFDLL LPAAMAKVAE EAGVYKATKH PLKTFYLAIT AGVFISIAFV FYITATTGTG
AMPYGMAKLI GGICFSLGLI LCVICGADLF TSTVLIVVAK ASGRITWGQL AKNWLNVYFG
NLIGALLFVL LMWLSGEYMT ANGQWGLNVL QTADHKMHHT FIEAVCLGIL ANLMVCLAVW
MSYSGRSLMD KAFIMVLPVA MFVASGFEHS IANMFMIPMG IVIRDFATPE FWTAVGSSPE
SFSHLTVMSF ITDNLIPVTI GNIIGGGLLV GLTYWVIYLR GNEHH
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