ID Q7D456_CLOAB Unreviewed; 563 AA.
AC Q7D456;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Acetolactate synthase {ECO:0000313|EMBL:AAK81574.1};
GN Name=alsS {ECO:0000313|EMBL:AAK81574.1};
GN OrderedLocusNames=CA_C3652 {ECO:0000313|EMBL:AAK81574.1};
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK81574.1, ECO:0000313|Proteomes:UP000000814};
RN [1] {ECO:0000313|EMBL:AAK81574.1, ECO:0000313|Proteomes:UP000000814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000313|Proteomes:UP000000814};
RX PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; AE001437; AAK81574.1; -; Genomic_DNA.
DR PIR; C97348; C97348.
DR RefSeq; NP_350234.1; NC_003030.1.
DR RefSeq; WP_010966914.1; NC_003030.1.
DR AlphaFoldDB; Q7D456; -.
DR STRING; 272562.CA_C3652; -.
DR GeneID; 45000150; -.
DR KEGG; cac:CA_C3652; -.
DR PATRIC; fig|272562.8.peg.3841; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_2_9; -.
DR OMA; GFPIKPQ; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02010; TPP_ALS; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF129; ACETOLACTATE SYNTHASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000814};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 23..139
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 208..341
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 399..545
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62563 MW; 65A48C17ED327256 CRC64;
MNENLKQDKD SEISKTEDEE SSMNTAELVV KCLENENVEY IFGIPGEENL ALIKALTKSP
IKFITTRHEQ GAAFMADVYG RLTGRPGVCL STLGPGATNL MTGVADANLD GAPLIAITGQ
VGTDRMHIES HQHLDLVAMF APVTKWNKQI VRPDTAPEIV RKAFKTAVDE KPGACHIDLP
QNIADMPVQG KPLRHTVTDK SFAAYSSIEK AAIAISRAKS PLILSGNGAI RSKASKAVLD
MAERLNIPVA NTFMGKGIIP FNHPLSLWSM GLAQKDYINR IFEKTDLVIA IGYDIVEYSP
KKWNSKGEIR IIHIGEKKAE VNNSYLPEVE VIGDISDSIQ EIIRRSDRIE TPKQALKIKE
DMHKNYEEYS DDQSFPMKPQ KVLYDLRRVM GEDDIVISDV GAHKMWIARN YHCYKPNTCI
ISNGFASMGI AIPGALAAKL VNPDKKVVAV TGDGGFMMNS QELETALRIG TPFVTLIFND
SNYGLIKWKQ EERYGESAYI NFTNPDFKMY AESMGLKGYR ITKAEELIPT LEEAFSQKVP
SVIDCAVDYS ENLKLSHKLE ELK
//