ID Q7MEK8_VIBVY Unreviewed; 446 AA.
AC Q7MEK8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Arylsulfatase regulator {ECO:0000313|EMBL:BAC96688.1};
GN OrderedLocusNames=VVA0662 {ECO:0000313|EMBL:BAC96688.1};
OS Vibrio vulnificus (strain YJ016).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=196600 {ECO:0000313|EMBL:BAC96688.1, ECO:0000313|Proteomes:UP000002675};
RN [1] {ECO:0000313|EMBL:BAC96688.1, ECO:0000313|Proteomes:UP000002675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJ016 {ECO:0000313|EMBL:BAC96688.1,
RC ECO:0000313|Proteomes:UP000002675};
RX PubMed=14656965; DOI=10.1101/gr.1295503;
RA Chen C.Y., Wu K.M., Chang Y.C., Chang C.H., Tsai H.C., Liao T.L., Liu Y.M.,
RA Chen H.J., Shen A.B., Li J.C., Su T.L., Shao C.P., Lee C.T., Hor L.I.,
RA Tsai S.F.;
RT "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL Genome Res. 13:2577-2587(2003).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR EMBL; BA000038; BAC96688.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7MEK8; -.
DR STRING; 672.VV93_v1c36630; -.
DR KEGG; vvy:VVA0662; -.
DR eggNOG; COG0641; Bacteria.
DR HOGENOM; CLU_009273_10_0_6; -.
DR Proteomes; UP000002675; Chromosome II.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21120; SPASM_anSME; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR034491; Anaerob_Ser_sulfatase-maturase.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR047207; SPASM_anSME.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR NCBIfam; TIGR03942; sulfatase_rSAM; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF3; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR SFLD; SFLDF00285; anaerobic_Ser-type_sulfatase-m; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDG01384; thioether_bond_formation_requi; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 39..281
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 446 AA; 51103 MW; 97653A133CBC72A2 CRC64;
MPKLRQQKRE ILMQKVTPRH STAMPIVPLK TAAKPEANQS YQRRFHVMAK PGGAKCNIDC
QYCFYLHKEA LLHQKKQPQM SEELLERFIK SYIASQDGDE IVFSWQGGEP TLLGLDYFRK
VVELQKKYQP VGVRIENDLQ TNGILLNDEW CQFLAEHQFL VGLSIDGPRE IHDKYRRTRS
GKPTFDLVMK SVETLKKYGV KFNALVAVNR HNAQYPREVY RFLTQELGAT YLQFTPVVEA
NGFQTTAPQF WNEQMIPVVG SELAKPGHPM SVVTDWSVDP QQWGEFLIAT FEEWVNNDLG
RVLVNLFETA VAQVMGLPSQ LCVTSEFCGK GLAIEHNGDV FSCDHYVYPE YQLANIQQHD
LSELAMSTRQ YTFGMAKRES LPSYCLKCPY LQYCWGECPK NRLIKSSDGE VGLNYLCPGI
KAFFDYALPM LVGITQILKA PNDRRE
//
