ID MUTS_VIBVY Reviewed; 853 AA.
AC Q7MHR2;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=VV2806;
OS Vibrio vulnificus (strain YJ016).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=196600;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJ016;
RX PubMed=14656965; DOI=10.1101/gr.1295503;
RA Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA Lee C.-T., Hor L.-I., Tsai S.-F.;
RT "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL Genome Res. 13:2577-2587(2003).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC95571.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000037; BAC95571.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_043877315.1; NC_005139.1.
DR AlphaFoldDB; Q7MHR2; -.
DR SMR; Q7MHR2; -.
DR STRING; 672.VV93_v1c25180; -.
DR KEGG; vvy:VV2806; -.
DR PATRIC; fig|196600.6.peg.2798; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000002675; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..853
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115167"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 853 AA; 94485 MW; 4525B67031103E96 CRC64;
MKAEQQHTPM MQQYLRLKAE NPDILLFYRM GDFYELFYDD AKKASQLLDI SLTKRGASAG
EPIPMAGVPF HAVEGYLAKL VQLGESVAIC EQVGDPATSK GPVERKVVRI VTPGTVTDEA
LLSERLDNLI AAIYHHNGKF GYATLDVTSG RFQLVEPQSE EAMAAELQRT SPRELLFPED
FEPVHLMTGR NGNRRRPVWE FELETAKQQL NQQFGTKDLV GFGVENAMLG LCAAGCLIQY
VKDTQRTALP HIRALTYDRQ DDSVILDAAT RRNLELTQNL AGGSDNTLAA VLDRCATPMG
SRMLKRWIHQ PMRCITTREH RLDAIAELKE QALFSDIHPV VKQIGDIERI LARLALRSAR
PRDLARLRHA MQQLPELAQT LSSLGNSHLK SLATAAAPMD DVCELLERAI KENPPVVIRD
GGVIAEGYSA DLDEWRDLAD GATGYLEKLE EEERDRHGID TLKVGYNNVH GFYIQVSRGQ
SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL AIEKQLWEEL FDLLLPHLAR
LQELAAAVAQ LDVLQNLAER ADTLDYCRPN LTKDPVVHIT AGRHPVVEQV TSDPFIANPI
ELNSQRKMLI ITGPNMGGKS TYMRQTALIA LMAHIGSYVP AESATIGSID RIFTRIGASD
DLASGRSTFM VEMTETANIL HNATANSLVL MDEIGRGTST YDGLSLAWAS AHWLATQIGA
MTLFATHYFE LTELPNQLPH LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
PKTVIKNARQ KLSQLELLSA EGSQPKARTV DIANQLSLIP EPSEVEQALA SIDPDDLTPR
QALEALYRLK KML
//
