ID Q7MJI3_VIBVY Unreviewed; 488 AA.
AC Q7MJI3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=L-fuculokinase {ECO:0000256|HAMAP-Rule:MF_00986};
DE EC=2.7.1.51 {ECO:0000256|HAMAP-Rule:MF_00986};
DE AltName: Full=L-fuculose kinase {ECO:0000256|HAMAP-Rule:MF_00986};
GN Name=fucK {ECO:0000256|HAMAP-Rule:MF_00986};
GN OrderedLocusNames=VV2178 {ECO:0000313|EMBL:BAC94942.1};
OS Vibrio vulnificus (strain YJ016).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=196600 {ECO:0000313|EMBL:BAC94942.1, ECO:0000313|Proteomes:UP000002675};
RN [1] {ECO:0000313|EMBL:BAC94942.1, ECO:0000313|Proteomes:UP000002675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJ016 {ECO:0000313|EMBL:BAC94942.1,
RC ECO:0000313|Proteomes:UP000002675};
RX PubMed=14656965; DOI=10.1101/gr.1295503;
RA Chen C.Y., Wu K.M., Chang Y.C., Chang C.H., Tsai H.C., Liao T.L., Liu Y.M.,
RA Chen H.J., Shen A.B., Li J.C., Su T.L., Shao C.P., Lee C.T., Hor L.I.,
RA Tsai S.F.;
RT "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL Genome Res. 13:2577-2587(2003).
CC -!- FUNCTION: Catalyzes the phosphorylation of L-fuculose.
CC {ECO:0000256|HAMAP-Rule:MF_00986}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate;
CC Xref=Rhea:RHEA:12376, ChEBI:CHEBI:15378, ChEBI:CHEBI:17617,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57846, ChEBI:CHEBI:456216;
CC EC=2.7.1.51; Evidence={ECO:0000256|HAMAP-Rule:MF_00986};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00986};
CC -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-lactaldehyde
CC and glycerone phosphate from L-fucose: step 2/3. {ECO:0000256|HAMAP-
CC Rule:MF_00986}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000256|HAMAP-
CC Rule:MF_00986, ECO:0000256|RuleBase:RU003733}.
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DR EMBL; BA000037; BAC94942.1; -; Genomic_DNA.
DR RefSeq; WP_011150691.1; NC_005139.1.
DR AlphaFoldDB; Q7MJI3; -.
DR STRING; 672.VV93_v1c19190; -.
DR KEGG; vvy:VV2178; -.
DR PATRIC; fig|196600.6.peg.2195; -.
DR eggNOG; COG1070; Bacteria.
DR HOGENOM; CLU_009281_11_2_6; -.
DR UniPathway; UPA00563; UER00625.
DR Proteomes; UP000002675; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008737; F:L-fuculokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042355; P:L-fucose catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07773; FGGY_FK; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00986; Fuculokinase; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR013450; Fuculokinase.
DR NCBIfam; TIGR02628; fuculo_kin_coli; 1.
DR PANTHER; PTHR43095; SUGAR KINASE; 1.
DR PANTHER; PTHR43095:SF5; XYLULOSE KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00986};
KW Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_00986};
KW Fucose metabolism {ECO:0000256|ARBA:ARBA00023253, ECO:0000256|HAMAP-
KW Rule:MF_00986};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00986, ECO:0000256|RuleBase:RU003733};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00986};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00986,
KW ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 4..247
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 256..443
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 488 AA; 53537 MW; FAAAEF6AB05319D6 CRC64;
MSVVIVLDCG ATNLRAIAID SQGKIVASYF VKNETKQDIN NPDYHIWDFE QIWTKLVECG
QKVIAEVGAK NVLALTVTTF GVDGAPFDNQ GNQLYPIISW KCPRTVPVMK QVEQELDRLQ
LYRDNGIGDY SFNTLYKLRW FQQHQPQLFE QMDKFVFISS MITHQLTGVW STDYTMAGTS
MMTDLTLCNW NPAVLEYLGL SEEQFPPLVM AGDVIGSVTS DIAKLLGLGA DVPVISAGHD
TQFALVGSGA AENQAFLSSG TWEILMARSQ RPQLDVHALQ HGVTVELDSV KGFYNPAIQW
LSSAVVEWVA NQFFTAEQAS GELYKVMIEE AREVGNGASG VVFKPNFTTN ADGIGQGAIE
GLGLHTNRGQ IARAVFEGLS KQLKQRFDYL SQLCQLSDGP VVVVGGGTKN DLWNQLRADA
LQRSLHIVEQ AEATVIGAAM FAFTGSGFYP DIDSAQAQMK PSLRVVNPSL LNTPPLESKT
VQQESTHA
//
