ID MDTH_PHOLL Reviewed; 401 AA.
AC Q7N568;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=plu2089;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01) (Photorhabdus luminescens subsp. laumondii).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01529}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR EMBL; BX571866; CAE14382.1; -; Genomic_DNA.
DR RefSeq; WP_011146344.1; NC_005126.1.
DR AlphaFoldDB; Q7N568; -.
DR SMR; Q7N568; -.
DR STRING; 243265.plu2089; -.
DR GeneID; 24166548; -.
DR KEGG; plu:plu2089; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_60_2_6; -.
DR OrthoDB; 56516at2; -.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd17329; MFS_MdtH_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR HAMAP; MF_01529; MFS_MdtH; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR022855; Multidrug-R_MdtH.
DR PANTHER; PTHR23517:SF2; MULTIDRUG RESISTANCE PROTEIN MDTH; 1.
DR PANTHER; PTHR23517; RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..401
FT /note="Multidrug resistance protein MdtH"
FT /id="PRO_0000173346"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 78..95
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ SEQUENCE 401 AA; 44383 MW; 046A2631B285ED7C CRC64;
MSLVSQARSL GKYFLLFDNL LVVLGFFVVF PLISIHFVEQ LGWAALVVGF ALGLRQFVQQ
GLGIFGGAIA DRFGAKPMIV TGMLLRALGF AFIALATEPW ILWLACILSA LGGTLFDPPR
TALVIKLTRP HERGRFFSLL LMQDSAGAVI GALIGSWLLQ YDFQFVCWTG AGVFVLAAIW
NALFLPAYRI STTRTPIWEG MERVIKDRRF FTYVLTLTGY FMLSVQVMLM FPIIVNEIAG
TPAAVKWMYA IEATLSLTLL YPIARWSEKR FRLEQRLMAG LFLMSLSMFP VGLIGEINTL
FGLICLFYLG TVTAEPARET LSASLADPRA RGSYMGFSRL GLALGGALGY TGGGWLYDTG
HALNIPQLPW FLLGIIGLIT LYALHRQFNQ RKIESAMLSG N
//
