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Database: UniProt
Entry: Q7NDE0_GLOVI
LinkDB: Q7NDE0_GLOVI
Original site: Q7NDE0_GLOVI 
ID   Q7NDE0_GLOVI            Unreviewed;       427 AA.
AC   Q7NDE0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   08-MAY-2019, entry version 106.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   Name=thrA {ECO:0000313|EMBL:BAC92236.1};
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales;
OC   Gloeobacteraceae; Gloeobacter.
OX   NCBI_TaxID=251221 {ECO:0000313|EMBL:BAC92236.1, ECO:0000313|Proteomes:UP000000557};
RN   [1] {ECO:0000313|EMBL:BAC92236.1, ECO:0000313|Proteomes:UP000000557}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421 {ECO:0000313|Proteomes:UP000000557};
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; BA000045; BAC92236.1; -; Genomic_DNA.
DR   RefSeq; NP_927241.1; NC_005125.1.
DR   RefSeq; WP_011144279.1; NC_005125.1.
DR   STRING; 251221.35214870; -.
DR   EnsemblBacteria; BAC92236; BAC92236; BAC92236.
DR   GeneID; 2602698; -.
DR   KEGG; gvi:gvip559; -.
DR   PATRIC; fig|251221.4.peg.4324; -.
DR   eggNOG; ENOG4105D6E; Bacteria.
DR   eggNOG; COG0460; LUCA.
DR   InParanoid; Q7NDE0; -.
DR   KO; K00003; -.
DR   OMA; FEASVCG; -.
DR   OrthoDB; 1464088at2; -.
DR   PhylomeDB; Q7NDE0; -.
DR   BioCyc; GVIO251221:G1G3K-4347-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000557};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000557};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      348    425       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    203    203       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     103    103       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     188    188       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   427 AA;  45324 MW;  F47CB9E5ABE26E19 CRC64;
     MATPLRLALI GLGTVGSGVL RILHDTAGRD ARLGTVQVVG VAVRDLERPR DLPVLPPLTD
     DPFSLVRDPE VDVVAEVMGG VDLPYRLLTA ALKAGKHVIT ANKALLARHG QELFALARAQ
     NRQLRYEAAV GGGIPLIQPL EQCLGANRIH SVTAIINGTT NYILTQMATR QMAYTQALAE
     AQALGYAEAD PAADVEGADA QEKLTILASI AFRIPLPPLE AIYREGITAI DLPDVINAQQ
     LGFGIKLLAL AERCPDGRLD LRVHPTLVPV DHPLSRVDGA YNAVLIEAEP VGSIMFFGPG
     AGGGPTASAV ISDLINILAD RPAGPTPADF AQPPPGYLSI DEVQTRFYIR LRALDRPGVV
     GHIGQIFGRH SVSLASIVQK NPRGAAAELV IITHDVAEAR LRAALAELRA SSEVQDFCTA
     IRVLPEG
//
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