ID MUTS_GLOVI Reviewed; 890 AA.
AC Q7NLT8;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=gll1033;
OS Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Gloeobacterales; Gloeobacteraceae;
OC Gloeobacter.
OX NCBI_TaxID=251221;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29082 / PCC 7421;
RX PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA Tabata S.;
RT "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT cyanobacterium that lacks thylakoids.";
RL DNA Res. 10:137-145(2003).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; BA000045; BAC88974.1; -; Genomic_DNA.
DR RefSeq; NP_923979.1; NC_005125.1.
DR RefSeq; WP_011141035.1; NC_005125.1.
DR AlphaFoldDB; Q7NLT8; -.
DR SMR; Q7NLT8; -.
DR STRING; 251221.gene:10758511; -.
DR EnsemblBacteria; BAC88974; BAC88974; BAC88974.
DR KEGG; gvi:gll1033; -.
DR PATRIC; fig|251221.4.peg.1058; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_3; -.
DR InParanoid; Q7NLT8; -.
DR OrthoDB; 9802448at2; -.
DR PhylomeDB; Q7NLT8; -.
DR Proteomes; UP000000557; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..890
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115100"
FT BINDING 685..692
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 98383 MW; 4738F818BDE4A6AE CRC64;
MADPATQLSQ WDFRRFARSD LTPMLQQYVE VKAQHPHCLL LYRMGDFYET FLADAEIVSR
ELEIVLTGRQ AGDKIGRIPM AGIPHHALER YCAQLIEKGY AVVICDQVES PEQAKERARQ
AKVARRSKSD GDAPLLPLLL EDGEQIDWEG AESVLVRRAV TRVLTPGTVL EDQLLVGRRN
NYLAALVQAG ECWGLAFADI STGEFQVTQL ESAEALVQEL LRLQPAEVLL SGDAPDPLVL
LRPGEASSER PECLPSQFCY TLRPRRYFEL DEARRLLMET FGVRSLEGFG CENLPLAVRA
AGGLVQHLLE TQRGVSIPLE GIRTYTLSQY LILDHQTRRN LELTQTVRDG AQYGSLLWAL
DRTRTVMGGR ALRRWLLQPL LDTRAIGRRQ DSVAELYDEG LLRERLQRIL ESVYDLERLA
GRCGSGTANA RDLVALGESL LKLPALAEAV AASTSPYLKA LQSIPVELER LGEKLRRTLV
DTPPLILTEG GLIRAGVHPE LEGMRGQLIE DRDWLVDLEA RERARTGIQT LKVGFNKAFG
YYLSISRGKA EKAPPEYLRK QTLTNEERYI TPELKERETR ILNAQQQTNQ LEYDIFNILR
QEAGRHVSAL RQVARRVAAL DALAGLAEVA VYHDYCRPVL GEGREVHIEA GRHPVIEQAI
PAGFFVPNDA RMGAEAEPDL IILTGPNMSG KSSFIRQVAL IQLLAQVGAF VPARGAVLGV
ADRIFTRVGA VDDLATGQST FMVEMTETAN ILNHATPRSL VLLDEIGRGT ATFDGLAIAW
AVAEYLASHI RCRTIFATHY HELNELASVV SGVANYQVTV QELADRIVFL HRVTPGGADR
SYGIEVGRLA GLPPSVVARA RTVLAQVEQH SQIAVGLRDS NGSASESAAG
//
