ID Q7PIK6_ANOGA Unreviewed; 1514 AA.
AC Q7PIK6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 24-JAN-2024, entry version 122.
DE SubName: Full=AGAP005943-PB {ECO:0000313|EMBL:EAA44113.4};
GN ORFNames=AgaP_AGAP005943 {ECO:0000313|EMBL:EAA44113.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA44113.4};
RN [1] {ECO:0000313|EMBL:EAA44113.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA44113.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA44113.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA44113.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA44113.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA44113.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA44113.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA44113.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA44113.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA44113.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA44113.4}.
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DR EMBL; AAAB01008960; EAA44113.4; -; Genomic_DNA.
DR RefSeq; XP_315976.4; XM_315976.4.
DR GeneID; 1276612; -.
DR VEuPathDB; VectorBase:AGAP005943; -.
DR HOGENOM; CLU_001722_0_0_1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09512; SAM_Neurabin-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR040645; Neurabin-1/2_PDZ.
DR InterPro; IPR043446; Neurabin-like.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR16154; NEURABIN; 1.
DR PANTHER; PTHR16154:SF6; SPINOPHILIN, ISOFORM J; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17817; PDZ_5; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 699..787
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1416..1481
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 14..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 799..829
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 879..930
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 956..990
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..544
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1514 AA; 165643 MW; 9A98700802B110E9 CRC64;
MCLSIRRFCI DCKGKSSRTD DEHSGEQQPP QQQGGVTRRT KVSSICFDVP AAGLGNRPPS
IISSSTTTDE GGFNEPSPEI KAKLKPAYEF DLPLPASPPR KVPIGEDRSP VGSPAEAKLT
YADLGYRVRP DGTECDEIYG EVDVYRSAKQ PAVGVPLARS QPSGAAASSG VPNGGQAAAQ
LAEPQVVAGP ATLANGRSGP TERVVYASIL PSSLGDNGST TTMATDSELA FMDGERDEAK
ILDFDELSEM GEKGYHSAQI LLDPTRTTLS QPADDDYSTK TLPEPPSLAS LRPPPIPEGP
PLDLQDTLKY ADASDNEQDS LLPDEMTADE AERLLSSRQR PLLSDEQARE VEQILLNNQA
KAEAEEPPAV RVVAGPRQQL PSVPEPAAKP QQLPQKQAPP TTTTAAVPST APTADEPDWL
KDVLEAPKNA TSSSSTAGSS MRDKPPPPPP PTSASRNNST TSHPEDTSIG NNTTCDLLNQ
TILLDSSSML ADSYVDTGDS IPSVTTTTSD SINLSKLEES AAETTGALED EGEATQEEEG
QEEEQQQQQQ QQQLASGRCV AAHRQQQQPQ APAEGSVSEA DVSADDESNN SAAGFYIPEY
PPVRCKEVYV NPDGVHFFED GNFWMEVPGL IEAERELDDD DLRGYVKKTT KVKFSCNPMQ
VFSTFSVNDY DRRNEDVDPV AASAEYELEK RVEKMDVFPV ELMKGPEGLG LSIIGMGVGA
DAGLEKLGIF VKTITDNGAA ARDGRIQVND QIIEVDGKSL VGVTQAYAAS VLRNTSGLVR
FQIGRERDPE NSEVAQLIRQ SLQADREKEE RVKRQLEDYI RRNAEISEDS TLPVSANSSV
SEGPVSPTTN AAESLFETEA ARSSDVESLR RILQEVRMLI KYQQTCNEAE LLNERVKQTE
RELANIKKEA NNYQNMLQQS QAQYLVLEKK YSRVKKILRD YQHRERDMIQ FQEYYLQHLQ
EKDTEYNALV KKLKDRVISL EQELQETQRK AGFPVILPYD SASLKLTPQM SRRQPPKPVF
QKLETDLSDT EFSDLSPDGE GEDGKTATVE RKVPATTKDD DLDVAVPQHE LLDNSLNKGK
SDLVARGGLA KRNLPGKRSH SNSGSDCALD ESDDDEGQLT RNATGTEGSH EYSGLYSTPQ
IVNRKVATLK GEDSGLPVYA QVNKERSSGG GHADHHQQQQ QQQQQHTTIP NIYRAAVGSD
NGKLNSSYGS DLNASSYDSD LGSSTDKLKD SGLSSDSWMY PSRRPKGLKG ITPPLLAEQL
KERLAEREGR RGSGGGLIDD GSSRDSSDDY SEINQQQRHI SPAASLSQNL LVEIKKAVNE
AQPKVKNILP QNLSPPGGNG PWQQQQQQQG AQSTSGGTMA GSSQGPPSPS SVSSGSTSPG
AYSPSRTLDL SGSTSSFSSD RIRDTHQWKN GPVEEWSNEQ VCQWLLGIGL DHHIPAFMQH
SVEGGALLQL DKPDFKILNV GGDDKKLLKR NIKELRRLNE KERKQNEKER REREKLFKKQ
EKKAEKEQKK RYQK
//
