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Database: UniProt
Entry: Q7PJH0_ANOGA
LinkDB: Q7PJH0_ANOGA
Original site: Q7PJH0_ANOGA 
ID   Q7PJH0_ANOGA            Unreviewed;      2118 AA.
AC   Q7PJH0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 4.
DT   23-MAY-2018, entry version 124.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=1278521 {ECO:0000313|VectorBase:AGAP004707-PD};
GN   ORFNames=AgaP_AGAP004707 {ECO:0000313|EMBL:EAA43760.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA43760.4, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA43760.4, ECO:0000313|Proteomes:UP000007062, ECO:0000313|VectorBase:AGAP004707-PD}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA43760.4,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA43760.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA43760.4};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAA43760.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA43760.4};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAA43760.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA43760.4};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [5] {ECO:0000313|EMBL:EAA43760.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA43760.4};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|VectorBase:AGAP004707-PD}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP004707-PD};
RG   VectorBase;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AAAB01008968; EAA43760.4; -; Genomic_DNA.
DR   RefSeq; XP_318122.4; XM_318122.4.
DR   ProteinModelPortal; Q7PJH0; -.
DR   STRING; 7165.AGAP004707-PA; -.
DR   EnsemblMetazoa; AGAP004707-RD; AGAP004707-PD; AGAP004707.
DR   GeneID; 1278521; -.
DR   VectorBase; AGAP004707-RD; AGAP004707-PD; AGAP004707.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   InParanoid; Q7PJH0; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   PhylomeDB; Q7PJH0; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    232    250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    409       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    777    800       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    821    838       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    850    874       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    905    927       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    985   1006       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1321   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1375       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1606   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1667   1686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1730   1753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1823   1843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1860   1895       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     51       {ECO:0000256|SAM:Coils}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2118 AA;  237566 MW;  9843358DB6CF4354 CRC64;
     MTEDSDSISE EERSLFRPFT RESLQAIEAR IADEEAKQRE LERKRAEGED EDEGPQPDPT
     LEQGVPVPVR MQGSFPPELA STPLEDIDSF YSNQRTFVVI SKGKDIFRFS ATNALYVLDP
     FNPIRRVAIY ILVHPLFSLF IITTILVNCI LMIMPTTPTV ESTEVIFTGI YTFESAVKVM
     ARGFILQPFT YLRDAWNWLD FVVIALAYVT MGIDLGNLAA LRTFRVLRAL KTVAIVPGLK
     TIVGAVIESV KNLRDVIILT MFSLSVFALM GLQIYMGVLT QKCIKEFPLD GSWGNLTDES
     WELFNSNDTN WFYSESGDIP LCGNSSGAGQ CDEGYICLQG YGKNPNYGYT SFDTFGWAFL
     SAFRLMTQDY WENLYQLVLR SAGPWHMLFF IVIIFLGSFY LVNLILAIVA MSYDELQKKA
     EEEEAAEEEA LREAEEAAAA KAAKLEAQQA AAAAAANPEI AKSPSDFSCH SYELFVGQEK
     GNDDNNKEKM SIRSEGLESV SEITRTTAPT ATAAGTAKAR KVSAASLSLP GSPFNLRRGS
     RGSHQFTIRN GRGRFVGVPG SDRKPLVLST YLDAQEHLPY ADDSNAVTPM SEENGAIIVP
     VYYANLGSRH SSYTSHQSRI SYTSHGDLLG GMTKESRLRN RSARNTNHSI VPPPNANNLS
     YAETNHKGQR DFDLTQDCTD DAGKIKHNDN PFIEPAQTQT VVDMKDVMVL NDIIEQAAGR
     HSRASDHGVS VYYFPTEDDD EDGPTFKDKA LEFLMKMIDI FCVWDCCWVW LKFQEWVAFI
     VFDPFVELFI TLCIVVNTLF MALDHHDMDP DMEKALKSGN YFFTATFAIE ATMKLIAMSP
     KYYFQEGWNI FDFIIVALSL LELGLEGVQG LSVLRSFRLL RVFKLAKSWP TLNLLISIMG
     RTVGALGNLT FVLCIIIFIF AVMGMQLFGK NYTDNVDRFP DHDLPRWNFT DFMHSFMIVF
     RVLCGEWIES MWDCMLVGDV SCIPFFLATV VIGNLVVLNL FLALLLSNFG SSSLSAPTAD
     NETNKIAEAF NRISRFSNWI KMNLANALKF VKNKLTSQIA SVQPTGKGVC PCISSEHGEN
     ELELTPDDIL ADGLLKKGIK EHNQLEVAIG DGMEFTIHGD LKNKAKKNKQ IMNNSKVIGN
     SISNHQDNKL DHELNHRGVS LQDDDTASIK SYGSHKNRPF KDESHKGSAE TMEGEEKRDA
     SKEDLGIDEE LDDEGEGDEG PLDGELIIHA EEDEVIEDSP ADCCPDNCYK KFPVLAGDDD
     APFWQGWGNL RLKTFQLIEN KYFETAVITM ILLSSLALAL EDVHLPQRPI LQDILYYMDR
     IFTVIFFLEM LIKWLALGFK VYFTNAWCWL DFIIVMVSLI NFVASLCGAG GIQAFKTMRT
     LRALRPLRAM SRMQGMRVVV NALVQAIPSI FNVLLVCLIF WLIFAIMGVQ LFAGKYFKCV
     DKNKTTLPHE IIPDVNACKA ENYSWENSPM NFDHVGKAYL CLFQVATFKG WIQIMNDAID
     SRDVSFVGKQ PIRETNIYMY LYFVFFIIFG SFFTLNLFIG VIIDNFNEQK KKAGGSLEMF
     MTEDQKKYYN AMKKMGSKKP LKAIPRPRWR PQAIVFEIVT NKKFDMIIML FIGFNMLTMT
     LDHYKQSETF SAVLDYLNMI FICIFSSECL MKIFALRYHY FIEPWNLFDF VVVILSILGL
     VLSDIIEKYF VSPTLLRVVR VAKVGRVLRL VKGAKGIRTL LFALAMSLPA LFNICLLLFL
     VMFIFAIFGM SFFMHVKDKS GLDDVYNFKT FGQSMILLFQ MSTSAGWDGV LDGIINEEDC
     LPPDNDKGYP GNCGSSTIGI TYLLAYLVIS FLIVINMYIA VILENYSQAT EDVQEGLTDD
     DYDMYYEIWQ QFDPDGTQYV RYDQLSDFLD VLEPPLQIHK PNRYKIISMD IPICRGDMMF
     CVDILDALTK DFFARKGNPI EETAELGEVQ QRPDEVGYEP VSSTLWRQRE EYCARLIQHA
     WKRYKQRHGG GTDASGDDLE IDACDNGCGG GNGNENDDSG DGATGSGDNG SQHGGGSISG
     GGGTPGGGKS KGIIGSTQAN IGIVDSNISP KESPDSIGDP QGRQTAVLVE SDGFVTKNGH
     RVVIHSRSPS ITSRTADV
//
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