ID Q7PM00_ANOGA Unreviewed; 1164 AA.
AC Q7PM00;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 3.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=AGAP009579-PA {ECO:0000313|EMBL:EAA14572.4};
DE Flags: Fragment;
GN ORFNames=AgaP_AGAP009579 {ECO:0000313|EMBL:EAA14572.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA14572.4};
RN [1] {ECO:0000313|EMBL:EAA14572.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA14572.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA14572.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA14572.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA14572.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA14572.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA14572.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA14572.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA14572.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA14572.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA14572.4}.
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DR EMBL; AAAB01008980; EAA14572.4; -; Genomic_DNA.
DR RefSeq; XP_318596.3; XM_318596.3.
DR AlphaFoldDB; Q7PM00; -.
DR STRING; 7165.Q7PM00; -.
DR PaxDb; 7165-AGAP009579-PA; -.
DR GeneID; 1278942; -.
DR KEGG; aga:AgaP_AGAP009579; -.
DR VEuPathDB; VectorBase:AGAP009579; -.
DR eggNOG; KOG2353; Eukaryota.
DR HOGENOM; CLU_004660_1_1_1; -.
DR OMA; ACDMRST; -.
DR OrthoDB; 2971287at2759; -.
DR PhylomeDB; Q7PM00; -.
DR ExpressionAtlas; Q7PM00; differential.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166:SF31; CA[2+] CHANNEL MUSCLE-SPECIFIC ALPHA2_DELTA SUBUNIT, ISOFORM A; 1.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 224..411
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA14572.4"
SQ SEQUENCE 1164 AA; 135699 MW; C5687FC7D0C1A060 CRC64;
PTSMEKWADN FGEELWDLAQ TMTKAMEITA KYKAYNARVE HKDGTALIQS IVENVGRMFI
RKMDAIKCII NLAEELSEQF EFNETLADNF SYYSSKYSNI DGRPEPEIPE TLQENMWMYR
NMSLNPDTHF FNISVNTSYS SVHVPQNVYD RYPWVLEALQ WSESLDDVFL QNYNSDPALS
WQYFGSYTGM LRHYPALEWN REHVDTFDCR KRSWYIETAT CSKDIVILLD NSGSMTGYRN
YIAQLTVKSI LDTFSNNDFI NIYKYSNDVE PLVPCFKDML VQATPENMRF FNEYVRELLP
EGYANVKKAF VAAFELLQKY REIRRCNESV SGCNQAIMLI TDGVPSNITE VFEAYNWFEN
GTKIPVRVFT YLLGREVTKV REIQWMACLN RGYYSHIQSL DEVQEEVLKY VTVIATPLVL
QGVEHPPTWT HAFTDTAVNK LSDDDEPPRL MIAVGAPAFD RKANHYNETR TARLLGVAGT
DIPVEDLDEL TLPYKLGVNG YSFIVSNNGY VLMHPDLRPV SNGRLKENYN SIDLTEIEQI
YDENITRQIE DMTGREMSPF ILELRQHLVD SQFGNMTKLP VRFHYDKMRR VSLEYQDYYY
APLENTPFSL GLVLPHDYGS TWIKVGDEIK RNQHMGLNIS DFFMGDNWKV HPDWVYCKYH
YLEGHEFKTP EDELRHFLNR LYEPTWKWSQ QYEPEPNEKE SDGPNCGRKT LDDDAYYCNK
ELVQLLIFDA KVTNNSYRNW EFENENERKI IEMYNATLRF VATMSGLTRW QFIFGEVEVD
TDSEFGDYHK KAIDETWYRS AILQHKIDPK SFVYSVPHES DPPEDGELKV TATMAIFPRD
GGLEAPGCVT GFQFTHSLMY DRFMEITSKT TCDGCIETCA SESRDCYVID HNGYVVLSET
SNHTGRFFGE IEGAIMQSMV DKEIFTMITV FDLQGLCEYE RVVENDAIAL LHPMKVFMLG
LKWLIAEIAI MLSRFDFWVH GIPSPDYFGR KYEYDDYDDT RPSKPKKIHV DEEEEYFNRP
KEIKKEIVYE PCDKKSNLYV MQQEKFSSKT YSYSCSLLYQ PYFAKRIPRS NLLMIIVENE
YKVDRVVLSA QPEVIYHNES EALPCVKTKL NFLPRRRLEE CYTEHPDEEL VAQCGSGTRL
TMQLTVVIST IVSLFVILSM CPNC
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