ID Q7PUU6_ANOGA Unreviewed; 1552 AA.
AC Q7PUU6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=AGAP001935-PA {ECO:0000313|EMBL:EAA00963.6};
GN ORFNames=AgaP_AGAP001935 {ECO:0000313|EMBL:EAA00963.6};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00963.6};
RN [1] {ECO:0000313|EMBL:EAA00963.6}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00963.6};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00963.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00963.6};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00963.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00963.6};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00963.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00963.6};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00963.6}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00963.6};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA00963.6}.
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DR EMBL; AAAB01008987; EAA00963.6; -; Genomic_DNA.
DR RefSeq; XP_321129.5; XM_321129.5.
DR STRING; 7165.Q7PUU6; -.
DR PaxDb; 7165-AGAP001935-PA; -.
DR GeneID; 1281190; -.
DR VEuPathDB; VectorBase:AGAP001935; -.
DR eggNOG; KOG0248; Eukaryota.
DR PhylomeDB; Q7PUU6; -.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17094; FERM_F1_Max1_like; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF8; MAX-1A; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 675..769
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 783..891
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 926..1144
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1155..1471
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 33..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 228..255
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 266..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..336
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 169466 MW; 8DB68068BA6426BA CRC64;
MDLATILLLL ETPPPKGGYH NFLIEHLAAG SGGGGTTSSA GASPAHKRLS PSPPGPPGTL
AASSARSTPI AGRKLGHHQH LLVRAKNYYC SNPMLNNSTN LYCNLDMESL EEMLKKVGRD
KMLGAQQKMR QFIKAVRAME QRLCDWPKSP NLTGPSPSPS SNPAAAAAAA GAQQAIAAAV
GAGPPGTEQP PKGTDPVKIS QLESAIEEQK QLRLQDARQV GAKAAKIKEW VTNKLRELEE
QNQLLREQNI KCNQQLELLR NHIATQSTRH SSVAPTQPVR TSLSLDVQDV KRRSGRRRSE
SLDPPEHRSL HAGSSGSGSH HHPHHHHHHH HHHHRRNLSM EPQELARDLA AAVDGLNLLP
LSQQQPHQSV AAPAQPQASG QGAHQHHPQP HHQHPAPPPP GMGASPGSDV DAVHDYAEIY
TPSREKAPAW LKGLPSGGSS TTTSDSVADL GTPRPPTPPL HRFPSWEAKI YQVANDGLAG
AGSNGAAGAG EEGESQDQES GSGMTASVGG GGGGNSRSQT VSGGYCDISV PVYATVKGRA
SQIRSMPFTG DSSDDSSDGE DGHGAMLTCA TSTHNSHNST STDNTETSTS GSASSPSKSL
KTSSSLSPAK RSGSESPKNK GRAISELSFE SGLSDDYAIP PDAVSTVDTT CMDASMPSLL
MRTSYADSPN KKMETLEKVG HLAKLGGKLK TWRKRWFVLK NGTLTYWKSQ HDVNRKPQGQ
IALDEACRIN RADGASTFEI DTGKKVYYLT ADSNATMDDW IRVLQNVQRR NATKLLLSRD
DQKPTVQGWV TKVKNGHAKK CWCVLLGKMF LYFKAPGETN PLGQINMRDA RVEEVEHVSD
SDSEEREDPA QSQARLTVAI YPQQQGGPTY LILPGKQERD NWLYHLTVVS GGGPNAGTQY
EQLIQKLMET DGDPNCVLWR HPILLHTKDN ITSPLTSLHS ETLQAEAIKL FKSCQLFLSV
AVNQPGIDYH VVLAQNALQQ CLDMPELQSE LICALIKQTS RHTGQKLGVG VQVNKKLAKP
ARQLLLCATQ SLFTCDTQQG SVAQANGSSP TSIQAPTVPP IDCKSNPPSY TFIQGWQLLA
LAVSLFVPKN SRLLWYLKLH LSRNADSKTD CGKYAAYCER ALERTMQNGG RETKPSRMEV
LSILLKNPYH HSLPHAIPVH MMNTTYQVVS FDGSTTIEEF HGTLAQEIGC RDATNGFTLF
SDDPIEKDLE HYLDPQAKLC DVISKWETAL REKGSGKFEN SRVIQLTYKN RLYWKHAAKL
ETEKERLLLC YQVNIQVVQG RFPLSRDLAL ELASLMAQID MGDFASDKSK TNSLQALDKF
YPYRYRDALN QEGLKELQEL LSAKWALLRG RSVLDCVRIY LTCARKWPFF GAALFQAKPR
HSDQAMAWLA VSEDALSVLE LSSMATIARY PYSSVMTFGG CQDDFMLVVS AEDTLQSASN
EQKLLFAMSK PKILEITLLI ADYMNALGHT LPGTPQMNTL TRNGSHRSIR SRALPGSLTG
TPAHNTLNSH ATHANNTLTS HSHTLNSHVS HTLSSHGQPD ILKSTPDHQR HK
//
