ID Q7PVA6_ANOGA Unreviewed; 1648 AA.
AC Q7PVA6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=AGAP012185-PA {ECO:0000313|EMBL:EAA00154.5};
DE Flags: Fragment;
GN Name=1280503 {ECO:0000313|EnsemblMetazoa:AGAP012185-PA};
GN ORFNames=AgaP_AGAP012185 {ECO:0000313|EMBL:EAA00154.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00154.5};
RN [1] {ECO:0000313|EMBL:EAA00154.5, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00154.5,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00154.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00154.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00154.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00154.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00154.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00154.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00154.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00154.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP012185-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP012185-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}.
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DR EMBL; AAAB01008986; EAA00154.5; -; Genomic_DNA.
DR RefSeq; XP_320350.4; XM_320350.4.
DR STRING; 7165.Q7PVA6; -.
DR PaxDb; 7165-AGAP012185-PA; -.
DR EnsemblMetazoa; AGAP012185-RA; AGAP012185-PA; AGAP012185.
DR GeneID; 1280503; -.
DR KEGG; aga:AgaP_AGAP012185; -.
DR VEuPathDB; VectorBase:AGAP012185; -.
DR eggNOG; KOG3527; Eukaryota.
DR HOGENOM; CLU_002715_1_0_1; -.
DR InParanoid; Q7PVA6; -.
DR OMA; WPLNFAV; -.
DR OrthoDB; 5391231at2759; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF21; PROTEIN 4.1 HOMOLOG; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT DOMAIN 35..317
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1459..1514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA00154.5"
SQ SEQUENCE 1648 AA; 178860 MW; F3D59DDD2A0F0C80 CRC64;
VSAVTMPGES TKAAEPAAAT SPSTPKKKPT NSKAALAKVT LLDGSILEVT IDRKCRGRDL
LNSVCAGLNI LEKDYFGLTY HTANDPRTWL DLERPVTKFF RSDPWDLSFE VKFYPPEPAQ
LQEDITRYHL CLQVRNDILE GRLPCSFVTH ALLGSYLVQS ELGDYDPAEM KDRSYLKDFK
IAPNQTPELL DKVIDLHKTH KSQTPAEAEL HYLENAKKLA MYGVDLHPAK DSEGVDIMLG
VCASGLLVYR DKLRINRFAW PKILKISYKR NNFYIKIRPG EFEQYESTIG FKLENHRAAK
KLWKACVEHH TFFRLMTPEP QQKSGLFPRL GSKYRYSGRT HYETRKTPVE RPAPDFKRSL
TGKRLSSRSM DALAQQEKER AAAKDAGKDA NKRHTMSHPP DHIPDLDSPT RGSRSPIKKD
KKERKPAGGV AVLPVAGKKD KPEQVSQKDE GLNGNNGQAE ALNSSAEEAT SPSGKRKGFL
FSSGRKSPKD KKDAGKEQPA KLMAAANGDG GSAGKKDPAK EAVQARAQDT ATNKTPQTTP
EKPGFTKPYE YSESEQDPAT AHKKNVKTRG FRYDEAPLRP NEESEAQLSP NSQSRRATGL
AFNYAPGEDQ KVRESVEKRK APGSPVAATA TAAGVKTDQL SPKSAARGLP GESEAEKGVR
TSARSYSPNK GRQVVDPLAS GAGTFRPLDD TSSAFIQGEQ AGAAAAAAAA AAAAAAEPAK
KKVKIMVIIS KFDPKTKKVD TAQGVVEHST GVLDTKTGQI ESKYGLIDPK AGTVVNFNAR
TGQNETFQGQ TDPKTGQLHI VGGVVDSASG KVDDTLGQAI MVVPDEDSVV EITTITSKVD
PNTGKIDTIN GEIEKSRGIL NHRSGILSTK YGDINPRTGE LRAIDPKTGK PSPAAAAVRP
VTVDRSNGQI MVVGVTDPKT NKLDNSQAHL IAIGNQVDPV VEVTSVLGKL DKKGLVDPKT
ITYDKSTGQL DTKDGKINTK YGQLDLVKQT VTFVDPKTGK TETKEIKVDP VSGQVLLKNQ
VNPKTGKTDK DYGRIVSIRI VHNRIDPVTG KHVPAAPVED KDIRVDAKTN QVWLPDGGKD
PKTGETIYTS SQVDPKTGFV ITIYGYLNPK TNEIERQAKM DPNMTKVDPT TGQIYAATGQ
VDEATGEPLF AATQINEEDG EIYTKVGRID PKSGRLVIIK IFIITKKDER GKPEELDVSA
VDLDPETGHI RNVAPKTLYL YKMRDPITGE TYNVDPNDPR IAGARTTVTQ TMTLSGEIDP
ATGRIKSEWG HIDPNTGDID PATAIRDPVT GKLILNYADI EPSHFGKNVT VTKETVPITR
EQFYEGIKHM DRKATRRDSE SSDDDMTAQY GKESIKEISS GTAAAGSKLN AAAAAAAAGT
PTVVKTTTKQ VITKNEDGVT HNVEEEVQNL GTGQIVYSTQ EHKADAPTGT DAGKFVTATA
VTTRTATTHE DLGTNAKTQQ LEEKTVATTT TQHGERQEQR VITQEVKTTA TVTSGDQYAR
RDSVSSSSSG DSGTPIDGPY GDESLSEVIY NKSYTGADNV VGASQIPEGP NVEHRRVVLD
DLAEGGTTTH GEIVSSQTVS SKTRTVETIT YKTERDGVVE TRVEQKITIQ SDGDPIDHDK
ALAEAIQEAT AMNPDMTVEK IEIQQQTQ
//
