ID Q7PXL5_ANOGA Unreviewed; 1000 AA.
AC Q7PXL5;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 24-JAN-2024, entry version 113.
DE SubName: Full=AGAP001468-PA {ECO:0000313|EMBL:EAA00868.5};
GN Name=1281707 {ECO:0000313|EnsemblMetazoa:AGAP001468-PA};
GN ORFNames=AgaP_AGAP001468 {ECO:0000313|EMBL:EAA00868.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00868.5};
RN [1] {ECO:0000313|EMBL:EAA00868.5, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00868.5,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00868.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00868.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00868.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00868.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00868.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00868.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00868.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00868.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP001468-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP001468-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AAAB01008987; EAA00868.5; -; Genomic_DNA.
DR RefSeq; XP_321659.5; XM_321659.5.
DR AlphaFoldDB; Q7PXL5; -.
DR STRING; 7165.Q7PXL5; -.
DR PaxDb; 7165-AGAP001468-PA; -.
DR EnsemblMetazoa; AGAP001468-RA; AGAP001468-PA; AGAP001468.
DR GeneID; 1281707; -.
DR KEGG; aga:AgaP_AGAP001468; -.
DR VEuPathDB; VectorBase:AGAP001468; -.
DR eggNOG; KOG1934; Eukaryota.
DR HOGENOM; CLU_002359_4_0_1; -.
DR InParanoid; Q7PXL5; -.
DR OMA; WVTDEII; -.
DR OrthoDB; 3385940at2759; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF130; PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 379..539
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 112599 MW; 18B5518E1430BC87 CRC64;
MNGNGLSNGH HRAESEENLH KPTTENGGNH QPHSGVQPES DEPNVDRLNC MGRLSYYVSM
AIGKFFYRLG YWIANNAWKT IGLCFLLVAL CSVGFIRFHK EKSPMKLWIP VGSKFQHDTN
WLIEHFKEGN RIETVMITAP DVLVPEVLQT IATITEEVEG FTFHNSEGQR LGWTDVCHKV
PLIAEYTADL SRRKRHAQDL EQPSVTTRRP KKSKPFFTPV IDVPSFLFCP MVERLELGCY
GSSLLELWKY NRTTIAGLSK EDIVDKLNRT TISPMTGHTV EFAELLGDVK RDWSGRIVSA
GSLVTHWFVH VNFSEVDSDV SGNAAGTEDW VTENAMLWEE RFLQIVTKAK RDLSNNETDI
YYAAGRSYGD ISEESMFKDM DKLIYGGIVM FVYMQLVLSK FSWTEFRVIL GSVGLMSVGM
GFVAGCGIVA ALGVSYGPVH TSLPFLLMGL GVDDMFVMMA CYRKVRKANP DLQLAERMGL
MLQHAGASIT VTSLTDIVAF IVGSITVIPS LQSFCIYAAA GVFMMFVFVI TFFVAIFTLD
ELRIASRRNS FLLWVVHDEK STSLWCEYNL MHRFINALYS KFLLTTVGKV LVILAVVLMT
GVNVHNLLKL RQKFDPNWFI PEETYYNQFV VKTHEHYPNA GYEAMLLFGH LNYTAELPNL
IGITHRLENR TDILHSFSSW VTAFQDFVHT HYDKDIAVDA LSEADFRKYL SKFLFSYEGG
RYQMNIKFAT KLKCGQPAPN ITVTTMDFKF RPFKEREEYL PAKYAVEDVL ASSNISTGDH
YRTLWAKIFG NWVTDEIIDT EIYRNISLAL IGVMFCSVVL IVNLQICFWI FVCVLLTLVN
VGGLMQVWGL TLDLVSCIAL QLAVGLCVDY AAHIGHTFLT INKGDRNRRS LETVLHIGAA
VFYGGGSTIL SLSILSGSQA YTYRTFFKIF LLVIAYGLFH GTILLPVILS LIGPAPYSGS
LNSLNTINNN PSPTKKVCRE GTEMISFIGK EKYTPNGTEL
//
