ID Q7PY32_ANOGA Unreviewed; 1616 AA.
AC Q7PY32;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 24-JAN-2024, entry version 125.
DE SubName: Full=AGAP001726-PA {ECO:0000313|EMBL:EAA00836.5};
GN ORFNames=AgaP_AGAP001726 {ECO:0000313|EMBL:EAA00836.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00836.5};
RN [1] {ECO:0000313|EMBL:EAA00836.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00836.5};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00836.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00836.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00836.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00836.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00836.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00836.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00836.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00836.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA00836.5}.
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DR EMBL; AAAB01008987; EAA00836.5; -; Genomic_DNA.
DR RefSeq; XP_321358.5; XM_321358.5.
DR PaxDb; 7165-AGAP001726-PA; -.
DR GeneID; 1281447; -.
DR KEGG; aga:AgaP_AGAP001726; -.
DR VEuPathDB; VectorBase:AGAP001726; -.
DR eggNOG; KOG4485; Eukaryota.
DR HOGENOM; CLU_001991_0_0_1; -.
DR InParanoid; Q7PY32; -.
DR OMA; CPPMFAS; -.
DR OrthoDB; 5477417at2759; -.
DR PhylomeDB; Q7PY32; -.
DR GO; GO:0005819; C:spindle; IBA:GO_Central.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IBA:GO_Central.
DR GO; GO:0061172; P:regulation of establishment of bipolar cell polarity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17117; RA_ANKFN1_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR039269; ANKFN1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR21437; UNCHARACTERIZED; 1.
DR PANTHER; PTHR21437:SF1; WIDE AWAKE; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT REPEAT 382..414
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1500..1601
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 97..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1616 AA; 175423 MW; 30DBBA30AAA7AA45 CRC64;
MVQKMLAPGK KDEISLPELV TRSLSNLELP SCRLPCPNLI PRPAEVPTTP EHKSAASSSC
SLSTLETQTA IAGASVQSLP IAIATGATSS TVSLTYEDEL SPGGSARRKT KPNSPLGSLL
AAVTSPVLSR ISSASSPNLS SNGSTLSSPS DRRMEYLLPH QQHPPGAGVQ GAGPIPSQQK
HQQQQQSVLL PKHGTARQHS PKIVKKTRHL STSSADEPDA CDRKAAGGGG GADKLSSSRH
VEAERNARNA QHLLLRAKRL TVSDNHNLSN SGSGNTAGTI ITPATTNSVD VLAVHNAKSV
SPLPSYTQQQ QQQSAAAPPS YWKQKKLPTK KQHKQLQAQL DKLTQINIHL HALFSAVEHG
HLEKARTILE STDVDVNSLN SDGLTPLDVA VLSNNRSMTK MLLQQGAIEN AHSVHAANSN
MGLHLNNLLC DAEATVHELG NFDGSQAGGL AGSERTGTGT NAGKTTFSNI IGSSGPSVTS
CTGSEIDKQV GLWERRVKGL RRMILGWEQT KPPDVPNRID IDVTGCSAVS LRLYEPLEGA
ITTKFKVQWS SRSDFSNVVG EREISEWCSF HGCMGAVCNL NELIQGRRYF FRACAGNVKG
WGPYKLSVPN CVVPSSWRDV ESRDNRFAGK QRNLDELFNA VRLARPEDAS EIALDGGQQQ
KRATKKKTTI KQLFSAASKF QKNLKRGIYL ACVLYHEDKL LLTNEDFVPV IEIDETFTSN
LHTDFYWLMK VACTWDDVKL LRMDMERNAS SAIHFRTKLL SAACQMQSAL SITDLGQLFY
RPLRDVHGTV VLSCVNCIKS PKAVSVLNSR WIPLNKIHKK LALSTEESSI NEILMNSIQE
QINYHQVSNI RLSRGLYVGY LKMQSSVDVI QVVVPVKAPN VLPHCKIRDN PHVSAEEWEL
IKQHKPSTIL EFRPKHQGPS EVQLHFLEML TKAVHNLFQY MDIPVDVAVA HRLYDVEVIE
LNADVSFLII CPPAESSCAV PGQKESLLQR GDLFSMPIQA FEMIHLKTYQ GSIIQKYSRL
SCILELDTML ANHLHREAFS SSELQKAKDR LAKLQELSGG LNTIWKGVRW LMDVIGYARD
RANMPELNMK QILDYKAAYF GKLPKHQHQQ PASDDQKKKG GSETQLLHPP GTAPNSFHKS
SPGRGSWPGP AVENTLGHNG LLDAEHSKSE QLLKYNSARF LNVSQAGSRK NSADSNSVAT
HSSYYSVTGV EPEKEFVVMP RLPPSRSEDT LNSSHLHHHL HHGHHHHHGG EGGKAIGPGG
AMGGAGVGGA GGAGKKRPPT IYSSYSATSS PLLNVRSPFL VPMGPANAAP SSPAGVLVAK
VPPVAVEDIE NSKQQPPVQQ TAATSAAAGT GQQPSLTTGG AVPFKLLTKK SRDQALKAIN
FIEREQQQEM EIFEETKPIL TTTYLKPTLA ALQNEAKSSY QQQPDSGAEQ TPREATAQLS
PVQASETLTP AGSVAITVEP SVPPAAATDL EPESGASEAP PGTDGAAAAP PTGGAAVTNA
TSILQVYAAY ETGLPSGTSL KLRVTPKTSA REVIDLVVKQ LNMAVVLKGR EGPIYSSERL
DNFCLVAVIG ARERCLRDDF RPLQLQNPWR KGRLYVRQKH DLLAAIEHSN RDTADI
//
