ID Q7Q0B3_ANOGA Unreviewed; 649 AA.
AC Q7Q0B3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=AGAP012367-PA {ECO:0000313|EMBL:EAA00139.4};
DE Flags: Fragment;
GN Name=1280344 {ECO:0000313|EnsemblMetazoa:AGAP012367-PA};
GN ORFNames=AgaP_AGAP012367 {ECO:0000313|EMBL:EAA00139.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00139.4};
RN [1] {ECO:0000313|EMBL:EAA00139.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00139.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00139.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00139.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00139.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00139.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00139.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00139.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00139.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00139.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP012367-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP012367-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AAAB01008986; EAA00139.4; -; Genomic_DNA.
DR RefSeq; XP_320189.4; XM_320189.5.
DR AlphaFoldDB; Q7Q0B3; -.
DR STRING; 7165.Q7Q0B3; -.
DR PaxDb; 7165-AGAP012367-PA; -.
DR EnsemblMetazoa; AGAP012367-RA; AGAP012367-PA; AGAP012367.
DR GeneID; 1280344; -.
DR KEGG; aga:AgaP_AGAP012367; -.
DR VEuPathDB; VectorBase:AGAP012367; -.
DR eggNOG; KOG0379; Eukaryota.
DR HOGENOM; CLU_027455_0_0_1; -.
DR InParanoid; Q7Q0B3; -.
DR OMA; KRWHAIV; -.
DR OrthoDB; 3674892at2759; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR CDD; cd22110; F-box_FBXO42; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011498; Kelch_2.
DR PANTHER; PTHR46432; F-BOX ONLY PROTEIN 42; 1.
DR PANTHER; PTHR46432:SF1; F-BOX ONLY PROTEIN 42; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT DOMAIN 19..82
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 360..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..393
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAA00139.4"
SQ SEQUENCE 649 AA; 72005 MW; FACEB65D9F318467 CRC64;
GEGRHPVRKF TTIFAPTMAA SINSLPNEIL EFIFSLLPPY EPLEHCAAVC KRWNLLATNV
RARKKSNLQK GLIDFNLCWK EILQVSTPRI AARFAHASSL HRNSMYVFGG ASSCDTTFND
LWRFDLSRRE WIRPISMGTY PSPKAGASLV CHNDLLILFG GWQHAYTPFH MCTLIDELHV
YNIAENRWTI HNQAYGPPPM TGHSASVHRN KMILFGGYQK NMENLRTSND IWVLDLERLV
WKKPAVSDLK PAPRYGQFQM AIGEDHILVL GGTGGVNRVF NDAWLLDMQR DTWVWKRVQI
KNKKSIVTHN WCYPACNVGS KVIVLGPTSP NDFQIIRPNR VPPMGRTRPT AEQLRNRIGA
APHGPMQAGE PNIPPRANLP PPPPAPMQPT LPRPSQGVSP KESNPSSGPG PSKPPSTVNS
GVPVVEARPG PSGLRTPSST APGPPSRSMP IIRSAFSRQS SEDDHLPKRF NQQNLEHNHM
AMVAFSVDSS NHASNASFSH ERKLELLRKL EDKISAIRRA KEAEQQQQQQ QQQQRHGIRE
VNNADRSINS TGGSPDPVTP KRVKRNGLAI FVCDVSNLLP TGGAEPCIEW QESKNSGLIA
GAPDHYTFST MINGNGELIV FGGLNKNHKS ENLCVSNSVH FLTVPTAVV
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