ID Q7Q0B8_ANOGA Unreviewed; 734 AA.
AC Q7Q0B8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 3.
DT 24-JAN-2024, entry version 108.
DE SubName: Full=AGAP012377-PA {ECO:0000313|EMBL:EAA00517.3};
GN ORFNames=AgaP_AGAP012377 {ECO:0000313|EMBL:EAA00517.3};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA00517.3};
RN [1] {ECO:0000313|EMBL:EAA00517.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00517.3};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA00517.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00517.3};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA00517.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00517.3};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA00517.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00517.3};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA00517.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA00517.3};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA00517.3}.
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DR EMBL; AAAB01008986; EAA00517.3; -; Genomic_DNA.
DR RefSeq; XP_320181.3; XM_320181.4.
DR AlphaFoldDB; Q7Q0B8; -.
DR PaxDb; 7165-AGAP012377-PA; -.
DR GeneID; 1280336; -.
DR KEGG; aga:AgaP_AGAP012377; -.
DR VEuPathDB; VectorBase:AGAP012377; -.
DR eggNOG; KOG2101; Eukaryota.
DR HOGENOM; CLU_014115_0_0_1; -.
DR OMA; YYFMQFL; -.
DR OrthoDB; 2877434at2759; -.
DR PhylomeDB; Q7Q0B8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS51207; PXA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..290
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
SQ SEQUENCE 734 AA; 83822 MW; D5BBFA6C55DCC77E CRC64;
MLFYHVKEVL LKFYQDDIAR VIAAAVLTVA LVCTLYVSYI IGLTILLFFI HGCAAAVFVL
NHKETFGRYI QRAKDFIGFK DYDASNRHEC DVCGNDRCPR HNRNVLVPKP SAGFYIEQPL
DDAIDRFFTH ILDSFIRSWY NQVTPDEEFL YHLKSTLRDA LCRLVLRAKE IDAPGVIMNR
LLPTVFIHYE IIAKMLLVDR VPMDKLAKTF VIDEYPIHPA VLNRGAEINY LRGVAKVLIP
RLFTAENTSC KIFFNLIKEL LTFWVLLPIM DVIADPNLIN LLIIIATDKR AKDGTRKVGD
AAKVQHCEKV KILDDFVGRS LRKLECGVPR DVTVPQEILW EDKDKLYYFM QFLIKEGSVE
LLQFYLDVDN LNKELEDPHI TTDPTKLSSL HQQSEKLLQK YQSMVKEVDG QFDGEETTPV
GTLTEAHERV RLKLEEKWFK QFSKTSEYFS LVYGGREIRE PHDKRYIDGT SGSGTKLSTK
FKEVIRGAVD GAPIEATESP TVWDALNDVH PSNNIYNSVT QKLRKEKGQS LDVFMSTFMH
SIEQSPDIGE DVVQEKEPVK KKTKIPGQSV VFGDLFELKK ASKNTHTTTL LSHSVRGPSQ
CFVYILVKVL NAPFLIVRLA LAFCCVSRKS VDTLINSLTA KLIRAGLKES RLAFLINLLR
EHVFLRKQPE PTPAMLLKRQ QEARKRLEDL RGGLGNLADV LQSPVLNKHL MYCLFDILLA
EMYPEFDESP SGKD
//
