ID Q7Q5F0_ANOGA Unreviewed; 753 AA.
AC Q7Q5F0;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 141.
DE SubName: Full=AGAP006474-PA {ECO:0000313|EMBL:EAA11877.4};
GN Name=1277081 {ECO:0000313|EnsemblMetazoa:AGAP006474-PB};
GN ORFNames=AgaP_AGAP006474 {ECO:0000313|EMBL:EAA11877.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA11877.4};
RN [1] {ECO:0000313|EMBL:EAA11877.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA11877.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA11877.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA11877.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA11877.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA11877.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA11877.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA11877.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA11877.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA11877.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP006474-PB}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP006474-PB};
RG EnsemblMetazoa;
RL Submitted (OCT-2022) to UniProtKB.
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DR EMBL; AAAB01008960; EAA11877.4; -; Genomic_DNA.
DR RefSeq; XP_316514.4; XM_316514.4.
DR AlphaFoldDB; Q7Q5F0; -.
DR STRING; 7165.Q7Q5F0; -.
DR PaxDb; 7165-AGAP006474-PA; -.
DR EnsemblMetazoa; AGAP006474-RB; AGAP006474-PB; AGAP006474.
DR GeneID; 1277081; -.
DR KEGG; aga:AgaP_AGAP006474; -.
DR VEuPathDB; VectorBase:AGAP006474; -.
DR eggNOG; KOG0393; Eukaryota.
DR HOGENOM; CLU_015517_0_0_1; -.
DR InParanoid; Q7Q5F0; -.
DR OMA; TIDKDCN; -.
DR OrthoDB; 2898387at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0032488; P:Cdc42 protein signal transduction; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR CDD; cd18499; BACK_RHOBTB; 1.
DR CDD; cd18299; BTB1_POZ_RhoBTB; 1.
DR CDD; cd18300; BTB2_POZ_RhoBTB; 1.
DR CDD; cd01873; RhoBTB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR PANTHER; PTHR24072:SF156; RHO-RELATED BTB DOMAIN CONTAINING, ISOFORM B; 1.
DR Pfam; PF00651; BTB; 3.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 2.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT DOMAIN 264..293
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 482..549
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 753 AA; 86229 MW; 40732CCC56C4BDB7 CRC64;
MDNEQPHQEL VKCVLVGDTA VGKTRLICAR ACNKHVSLSQ LLNTHVPTVW AIDQYRIYKD
VLERSWEIVD GVNVSLRLWD TFGDHDKDRR FAYGRSDVVL LCFSIANPVS LRNCRAMWYP
EIRKFCPDTP VILVGCKNDL RYMYRDETYL SYFGERSPFV RAARKSDLVM PDEARAVAKE
LGVAYYETSV FTYFGVNEVF ENAIRAALIA RREHRFWMTN LKRVQRPLLQ APFRPPKPPP
PEVTVITGTH TKDMLNMFNS QCYTDLVLIV GTIRFSVHRF MLASSSNAFH RLLMMDISDI
GARSSSESSM VSSTFGESTT ADFNEDTECL IRLEQNKVAP NRMWEQLKRR SSYQALPTVE
PKKDLYRELH HPVFQSIRVF QIDSGRHSYT QTQTVVQISK VITPQAMQQC LKFIYTGTID
RDCLDLQEIR QAAEFLELPQ LMVLLSNTQA NQSFMNDETI QHYSTCMKQN LEKYCVQNGI
FGDITFELDD GHMKAHRAML VARCDVMKAM LNGDFREAHA NLIVLPGVTE YTFHKLLCYL
YTDEIPPISA DKCLNLLELA NRLCLPRLLN LVECRVIEDL LRMSQNETSE AVEHCLRLLE
PVKLHNAHQL AEWCMSYLCV NYNSICRLSP RSLKGLHPDN QDYLREHRWP PVWYLKDYDY
YQRCMNELSR ELNSGKKDCT ADDKGCLCFS GVFFWLLGKS KRSAATAKSA IQAGTGKGAA
GAADQQDAVS TSLFQSNANS VNQLDPEHDA GDL
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