ID Q7Q758_ANOGA Unreviewed; 1239 AA.
AC Q7Q758;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=AGAP005490-PA {ECO:0000313|EMBL:EAA10906.4};
GN ORFNames=AgaP_AGAP005490 {ECO:0000313|EMBL:EAA10906.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA10906.4};
RN [1] {ECO:0000313|EMBL:EAA10906.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10906.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA10906.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10906.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA10906.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10906.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA10906.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10906.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA10906.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA10906.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA10906.4}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008960; EAA10906.4; -; Genomic_DNA.
DR RefSeq; XP_315491.4; XM_315491.4.
DR AlphaFoldDB; Q7Q758; -.
DR STRING; 7165.Q7Q758; -.
DR PaxDb; 7165-AGAP005490-PA; -.
DR GeneID; 1276178; -.
DR KEGG; aga:AgaP_AGAP005490; -.
DR VEuPathDB; VectorBase:AGAP005490; -.
DR eggNOG; KOG2353; Eukaryota.
DR HOGENOM; CLU_004660_1_1_1; -.
DR PhylomeDB; Q7Q758; -.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166:SF63; STRAIGHTJACKET, ISOFORM C; 1.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF13519; VWA_2; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1239
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004289897"
FT TRANSMEM 1031..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..446
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1239 AA; 142220 MW; AE15BFDB7AA1E68D CRC64;
MLYTGGRSSC GILAFTFLLF FAISITRSAD EPTTTIKYNV VQAWAAKLGG ELWHLGDFIT
RRKEVEESFK QAQVVNKNGA KIVEEMAKDL KYMMDAKVSA VKRIMDTAEN TAISFDEEPV
NQSFQYYNAK QMIEPGEIIT TPIPMIDEDP ADITTPIPPK EIVLTKKRHF FNEAVNTTVS
SVHVPTNVYD RATEVIKAIK WSEALDSIFY NNYIGDPTLT WQYFGSSSGF LRQFPATKWE
QDPVDLYDCR LRSWYIEAAN SPKDMLILVD SSGSMTGQRK DIAKHVVSNI LDTLGPNDYV
NIFTFSEEVA EVVPCFRDTL VQANMGNIRE LKLGMDNIET NEIANVSAAL TRAFELLEQF
RETRNGARCN QAIMLVSDGV PYSFDEVFEQ FNWKELPFIP VRVFTYLIGR EVADVKEIKE
MACRNQGYYV HLSTMAEVRE EVLNYIPVIA RPLVLNKREH PVVWSEIYAD VEDPKMTDWL
WEIKERAEQK ERFIDYRKNR VLFYSPEEQH RRMIMKQRMN QDPYSNTQKY NFMTTVSVPV
FDRRENATRV ANILGVAGAD VPIAEIKKYL KPHLLGVNGY AFIVTNNGYI LTHPDFRPVF
QDILKPAYNT VDMIEVELTD DDQGPREFNN QLLNMRESII NQSTGAKWIR VKYHFDEMKR
VSRTKRQYYW TPIKNTPFTL VVTYPETYGL NRLQIRTEDE IHRIHAKGSN VASFFTGNNW
KIHPDWVYCK YLNEHPNETF ATPELELKHF LERMKLGGWK WPSNRTPPPP EHAMFSNITG
KLPDKDYYYC DRGLMQALVY DAKVTEWFSK NVSGSGGNKD EKGNEFKQRF GITVSFLATH
SGLTRWQEYA TGADESKQAE PDFSETHNRA IDEVWYKRAV ELDRNSFVYS VPFDAGNRND
TLVTASHAIF HADGAREAPV AVVGFQFHHS ALYTLFKNIT SQCGHGDPRC EKTCFTGDYQ
CYVIDNNGFV VISEQLQETG AFFGEVKPAF MQRLLDDSIF RNVTVYDYQA VCFMAKGSIN
LGTVLQTPLR LLWWLLTNTF SYLVWVVMQL FLSLARAYDE MYDTGAYDVV PELGDLDDPT
LNRYKEPEFN KVLINRTRPE PCDHVITLYE LNMDVDPSVY TKEAHQCERP YVVLPIPSSN
LLLLVLDTLC PLPTHVPQLS TWPVEHDYNA SLACHKARSD PLPRRRPLTC INKHANESVI
ELCGDGSIPR LNVALLLALL AFGQCIGRRY TAGALFAYL
//
