GenomeNet

Database: UniProt
Entry: Q7QAH1_ANOGA
LinkDB: Q7QAH1_ANOGA
Original site: Q7QAH1_ANOGA 
ID   Q7QAH1_ANOGA            Unreviewed;      1532 AA.
AC   Q7QAH1;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 5.
DT   05-JUN-2019, entry version 138.
DE   RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
GN   ORFNames=AgaP_AGAP003702 {ECO:0000313|EMBL:EAA08933.5};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA08933.5, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA08933.5, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA08933.5,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001199-2,
CC         ECO:0000256|RuleBase:RU361183};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001199-
CC       2, ECO:0000256|RuleBase:RU361183};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAA08933.5}.
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DR   EMBL; AAAB01008888; EAA08933.5; -; Genomic_DNA.
DR   RefSeq; XP_313494.5; XM_313494.5.
DR   STRING; 7165.AGAP003702-PA; -.
DR   MEROPS; M12.011; -.
DR   EnsemblMetazoa; AGAP003702-RA; AGAP003702-PA; AGAP003702.
DR   GeneID; 1274378; -.
DR   KEGG; aga:AgaP_AGAP003702; -.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   InParanoid; Q7QAH1; -.
DR   KO; K13046; -.
DR   OrthoDB; 681837at2759; -.
DR   PhylomeDB; Q7QAH1; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00041; CUB; 5.
DR   CDD; cd04281; ZnMc_BMP1_TLD; 1.
DR   Gene3D; 2.60.120.290; -; 5.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR015446; BMP_1/tolloid-like.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR034036; ZnMP_TLD/BMP1.
DR   Pfam; PF01400; Astacin; 1.
DR   Pfam; PF00431; CUB; 5.
DR   PIRSF; PIRSF001199; BMP_1/tolloid-like; 1.
DR   PRINTS; PR00480; ASTACIN.
DR   SMART; SM00042; CUB; 5.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF49854; SSF49854; 5.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01180; CUB; 5.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00438935};
KW   Hydrolase {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973787};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2,
KW   ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS01068076};
KW   Protease {ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183,
KW   ECO:0000256|SAAS:SAAS00973802}.
FT   REGION      137    176       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   REGION      195    218       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   REGION      272    378       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   REGION      404    532       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   REGION      546    577       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   COMPBIAS    138    174       Polar. {ECO:0000256|MobiDB-lite:Q7QAH1}.
FT   COMPBIAS    275    303       Polar. {ECO:0000256|MobiDB-lite:Q7QAH1}.
FT   COMPBIAS    328    342       Basic. {ECO:0000256|MobiDB-lite:Q7QAH1}.
FT   COMPBIAS    343    357       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   COMPBIAS    358    378       Polar. {ECO:0000256|MobiDB-lite:Q7QAH1}.
FT   COMPBIAS    404    425       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   COMPBIAS    470    501       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                Q7QAH1}.
FT   COMPBIAS    505    519       Basic. {ECO:0000256|MobiDB-lite:Q7QAH1}.
FT   ACT_SITE    684    684       {ECO:0000256|PIRSR:PIRSR001199-1}.
FT   METAL       683    683       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL       687    687       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   METAL       693    693       Zinc; catalytic. {ECO:0000256|PIRSR:
FT                                PIRSR001199-2}.
FT   DISULFID    909    936       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   1532 AA;  171692 MW;  7341938C89220434 CRC64;
     MRNRKPSRAA VGAPRPSGWV PAIVMVIVAI NQLTEGLELN ETLITRRHQQ HRYTIDELLD
     ARFPKSISGD IDMDPCKSSG FMGDIAMPNV NYETEWQRQR MNKSLEQDIV KLKQEVYLEG
     LQVEEEGMTD MIRKKTKQRA STPLSGMTSA TGGAYAHSGT SYESENSITD SSGEPPVKAT
     IIDNRDNIIV PREPETTVAG GVGGDGERTG EKKATTANKK NATGAVRNID HDRIQSDTKD
     IVIDSISDNI ISNNHVSSRK VATYALPTKP PTAVTAAAGS HSVSTDSHPA QVAAGSNETK
     PMSSILAVGK LASSGGNGEQ YAVGQAGTRT RRRHRRRRRQ QQHPRLHDAD HTGDDPTSKT
     TSGKTPLNND GTVVNKNSYH SRLERLRVEL GTVTYSVRDR NLRSSHHNQH HHPDEEPLAE
     RSSQNRTPRK KRRRTGGDSP RRNHQHQDVI ANDGRKPPPT ANGNDDGNRS EQRANVDIDR
     ASSVDGMKQH GEAHGYDKSY HPRAQPQHQQ HRHRSEHHHL HEQAHGTHFT HAEPNVGADN
     GMNLHFRPDH KAPARAGKAQ DPPEPQHLPV EDDIDDDDAD RYHHRTIRAA TAKKERIWDF
     GVIPYEIDGN FSGMHKALFR QAMRHWENYT CIKFVERNPI DHPNYIVFTE RACGCCSFVG
     KRGNGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR ENHVVIEKNN IVVGQEYNFN
     KLTEDEVNSL GLPYDYDSIM HYARNTFSKG TYLDTIFPIE MPGRKRPEIG QRLRLSEGDI
     AQANLLYKCA KCGRTFQENS ASFTSPTYYS TTPPTEPERC EWRITATHGE RIVLNITDLD
     IYKSNSCRSD YLEIRDGYWH KSPILGKFCG SGKVNELIRS TGSRMLLTYT TTFRQASMRG
     FAANYEAICG GDMNLESGGR LESPNYPVDY LPNKECIWRI TVPKDYQVAL KFQSFEVENH
     DNCVYDYVEV RDGGSADSRL IGVFCGYKIP PDMKSTSNKL FVKFVSDGSV QKAGFSATFM
     KEVDECEHMD HGCEHECINT LGGYECACYI GYELHSDKKS CENACGGQLD TPNGTILSPS
     FPKEYPIMKE CVWEIVALPQ HKITLNFTHF DLEGNTFYQA SECEYDYVAV LSKSPDGTLH
     KHGSYCGYTV PAPITSEWNI LRVVFKSDKT IQKTGFAAVY FTDIDECAVN NGGCQQECKN
     TVGSYVCSCR NGYTLHDNGH DCKESGCKHE IFTPHGQILS PNYPDYYPPK KDCIWHFTTT
     PGHRIRLVFN VFDIEPHQEC AYDHIVIYDG NSPDSHTLGR FCGAKIPHPI SSSSNQMYMV
     FNTDTSVQRK GFFASHSTAC GGRLKATEVK NHFYSHIKFG SGMYDNGADC EWTIVADSGQ
     NVQLKFLSFE LEEEKMCSYD YVEVYGGLDD ESGPLHGKYC GNANPPEIIS MHEALMVRFR
     SDDTVGFKGF SAAYVAIKSN DDVLTTDEEG SDSSDIIPFP GSLKTVFIKQ GEDMDEEEED
     DDIDYEIYPN RPANSKVHVA VHNEIRSSQA ID
//
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