ID Q7QAZ4_ANOGA Unreviewed; 1061 AA.
AC Q7QAZ4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 4.
DT 24-JAN-2024, entry version 120.
DE SubName: Full=AGAP004272-PA {ECO:0000313|EMBL:EAA08681.4};
GN Name=GPRBOS {ECO:0000313|EMBL:EAA08681.4};
GN ORFNames=AgaP_AGAP004272 {ECO:0000313|EMBL:EAA08681.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA08681.4};
RN [1] {ECO:0000313|EMBL:EAA08681.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08681.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA08681.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08681.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA08681.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08681.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA08681.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08681.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA08681.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA08681.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA08681.4}.
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DR EMBL; AAAB01008880; EAA08681.4; -; Genomic_DNA.
DR RefSeq; XP_313193.4; XM_313193.3.
DR AlphaFoldDB; Q7QAZ4; -.
DR STRING; 7165.Q7QAZ4; -.
DR PaxDb; 7165-AGAP004272-PA; -.
DR GeneID; 1274116; -.
DR KEGG; aga:AgaP_AGAP004272; -.
DR CTD; 1274116; -.
DR VEuPathDB; VectorBase:AGAP004272; -.
DR eggNOG; KOG1056; Eukaryota.
DR HOGENOM; CLU_010513_0_0_1; -.
DR InParanoid; Q7QAZ4; -.
DR OMA; LQQCTQY; -.
DR OrthoDB; 3025222at2759; -.
DR PhylomeDB; Q7QAZ4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001640; F:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0005118; F:sevenless binding; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR InterPro; IPR002956; Bride_of_7less.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF173; PROTEIN BRIDE OF SEVENLESS; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01223; BRIDEOF7LESS.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 666..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 664..913
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|Pfam:PF00003"
FT REGION 67..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 116706 MW; F1F6CD15C46E6057 CRC64;
MAPGKWWHWS TRRAYVACLI GIVLTLCQTI PHAKGQRDNG SLVVVQALPP SYFSVTTPTA
TEPLLRHKAS TEPAELSEES FTSESSFLSS EDVSSSNNSQ PDHPNSSSET SSSSQEMEGL
SAQSAEDAQQ SMVVTAASNN QYETSSNTSP KLLAEPTEDH LIGNVTTRPM VTNATTTTTP
ASIAEDTTES ESTESNCTGR PFIDLARTGN LERYRHQRTF APVPTIRAGR SQRTSESQVQ
LLSARSGAGQ ELPPASGENE DVELHAAQYG YRMYRLEGEL MLTMMMETDD FGATLLAIDR
INDLRLLASG GDASIGLNII HLLNISLSQR TLQQEVNILK ECSTNTIGIF VSPRLWPSVR
LLSETLDYNI FPLPSTNDAL FTKAAHLLYE LPWTNGNSSA MVYSGSNELS TRFNAICRHE
HLCLENYPSS DTIYIQLGLE PAISFAINGT LVLVLTAHDR LYLPDLPVGA YVIAEAELNV
ASLGHSWERY GTSIRGSELL VTGGLLLEVI DLLNRPGSDC RNASIECMNN WKYHAKRSST
EVLNHLQLKN ATQSIKFELR QKRTIVHVRA NDTEPAATAD ADPDATELKL VASSNAITNY
TTVYGRLATS PDAPSKLGTI FYCAKEFEIR HPDFIERHHR PPVYYGTSTD AEEYGDMYWQ
LKMEAWVAAG LTVSSLGILL CAAILIFLIV RVCMDDILEG HPLGSILLLI SLILQFAAFI
PFSLEYTGYT TDLAGHRTDT MLTWNAHCTV KIFLVSMCYC MTFSLLLCRA IMLASIGSEG
GFLSHINGYI QSVICGFSTL VQLGLSTQLV IVLHANAHSI SCGEIYYGHW FWAVIAYDGV
LLVSLIFLAP FIFRSQRNYR EGLLLVTGSV LCLVIWTVWI PLCMFGYEWR EAAISLGMVA
TALAVLVGIM IPRCFLMVRS IARSDLVQAL PSLTSLAFAQ ANQFISDQSV YECVNPAMRQ
RSPTDDSFVM DQDLDEAYSA NSEIPTLPLR GQRRLRQENG TITMSTSNGT IGGNHNGTLV
SPMDRPVGNV THIAPNFYGI SNPYSCSDSI TSISPNKITR F
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