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Database: UniProt
Entry: Q7QEY5_ANOGA
LinkDB: Q7QEY5_ANOGA
Original site: Q7QEY5_ANOGA 
ID   Q7QEY5_ANOGA            Unreviewed;       542 AA.
AC   Q7QEY5;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 4.
DT   23-MAY-2018, entry version 105.
DE   SubName: Full=AGAP000211-PA {ECO:0000313|EMBL:EAA06347.4};
DE   SubName: Full=Triacylglycerol lipase {ECO:0000313|VectorBase:AGAP000211-PA};
GN   Name=1272054 {ECO:0000313|VectorBase:AGAP000211-PA};
GN   ORFNames=AgaP_AGAP000211 {ECO:0000313|EMBL:EAA06347.4};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA06347.4, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAA06347.4, ECO:0000313|Proteomes:UP000007062, ECO:0000313|VectorBase:AGAP000211-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA06347.4,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA06347.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA06347.4};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAA06347.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA06347.4};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAA06347.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA06347.4};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [5] {ECO:0000313|EMBL:EAA06347.4}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA06347.4};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|VectorBase:AGAP000211-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP000211-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AAAB01008846; EAA06347.4; -; Genomic_DNA.
DR   RefSeq; XP_310922.4; XM_310922.5.
DR   STRING; 7165.AGAP000211-PA; -.
DR   ESTHER; anoga-q7qey5; Insect_lipase.
DR   EnsemblMetazoa; AGAP000211-RA; AGAP000211-PA; AGAP000211.
DR   GeneID; 1272054; -.
DR   KEGG; aga:AgaP_AGAP000211; -.
DR   VectorBase; AGAP000211-RA; AGAP000211-PA; AGAP000211.
DR   eggNOG; ENOG410IHRX; Eukaryota.
DR   eggNOG; ENOG410Y92X; LUCA.
DR   HOGENOM; HOG000038552; -.
DR   InParanoid; Q7QEY5; -.
DR   OrthoDB; EOG091G0DJ5; -.
DR   PhylomeDB; Q7QEY5; -.
DR   Proteomes; UP000007062; Chromosome X.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306}.
FT   DOMAIN       54    375       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   ACT_SITE    207    207       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    235    235       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    323    323       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   542 AA;  61415 MW;  3964829EE5A32767 CRC64;
     MEISNTTGFL LQTILWMANH EYNNSLINVI HNQTLSADSN KTSGEFSLAE DVRCYGVYGC
     FPITPPWIDE KRPVAYHPQS PATVDVRYPV FTKPNTDHPK FIDINDPASV RHLGINPKGR
     IYFITHGYIE SGDRPWIRQM VNALIENDPD RTASCVVIDW RKASNPPYTQ TCANIRLIGA
     ITAHVIYLLY EELNMKNLDK VHLLGHSLGS HLCGYAGYHL QKDFGLKLGR ITGLDPAEPL
     FSDTDPLVRL DRSDAKFVDV IHSDGSEWVS KGGLGMYQPI GHVDFYPNGG YNQPGCSDPM
     NKFIRKHDDS FFWGFQEFFG CNHLRCHQFL TDSILHRCPF VGIGCESYAQ FLRGECFECD
     RDGHYCVEFG LKAQESYSRL IENGVIKDPN APLSVYMITG AEPPYCRSHF RITMSVSDEE
     ESLIHGGEIG KMSFELHGEG GVRSGKMDFS KDPVYFEPGG NYSAIMAGSH VAKLLKVMLT
     WEYRTNPLNP LTWRLLVVPR VYVQRIRIQL MEQRTSVVVC PLNDAPVRAD QENEFKSEYC
     RS
//
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