ID Q7QFL5_ANOGA Unreviewed; 914 AA.
AC Q7QFL5;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 5.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=AGAP000551-PA {ECO:0000313|EMBL:EAA06290.5};
GN Name=1271673 {ECO:0000313|EnsemblMetazoa:AGAP000551-PA};
GN ORFNames=AgaP_AGAP000551 {ECO:0000313|EMBL:EAA06290.5};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA06290.5};
RN [1] {ECO:0000313|EMBL:EAA06290.5, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA06290.5,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA06290.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA06290.5};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA06290.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA06290.5};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA06290.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA06290.5};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA06290.5}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA06290.5};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP000551-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP000551-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
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DR EMBL; AAAB01008846; EAA06290.5; -; Genomic_DNA.
DR RefSeq; XP_310532.5; XM_310532.5.
DR AlphaFoldDB; Q7QFL5; -.
DR STRING; 7165.Q7QFL5; -.
DR PaxDb; 7165-AGAP000551-PA; -.
DR EnsemblMetazoa; AGAP000551-RA; AGAP000551-PA; AGAP000551.
DR GeneID; 1271673; -.
DR KEGG; aga:AgaP_AGAP000551; -.
DR VEuPathDB; VectorBase:AGAP000551; -.
DR eggNOG; KOG0451; Eukaryota.
DR HOGENOM; CLU_004709_1_0_1; -.
DR InParanoid; Q7QFL5; -.
DR OMA; TPAQYYH; -.
DR OrthoDB; 3597773at2759; -.
DR Proteomes; UP000007062; Chromosome X.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 563..768
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 914 AA; 102565 MW; 6B5ABC437ABE5EC6 CRC64;
MLGRLLLSRG YHSTKGVFGH RPRPTTRYEG LAAAVLDKRN ANANVYRWVE AYRNHGHRMA
AIDPVKFHLA DEAASEPLPE LQYARYGLGA ADRIDPRGLL NVPAAQQPLS MAELDALLAR
MYCGSCSIEL AFIESEQERE WVAGRYEQLF QHELTEGERR ELAELMLKSQ AFDQFLAVKF
PTVKRYGGEG AESMMAFYWE LFRSAGEHEL RNVVIGMPHR GKLNVLTTMF GTRPAKIFKK
FKGHPEFPAD AQAMCDIASH FHTSTDIIVG GKTFHLNMLH NPSHLEAVNP VSMGKARAKQ
LALADGPYDT SGTDRRSKVL NVQVHGDAAF PGQGINQECL MMAAVPHYEV EGTVHLIVNN
QVGFTTPAER GRSTRYVSDL AKAIMAPVVH VNGDDPEALA GVTQLAIEYR QKFGKDFFID
LNCYRRWGHN ELDDPTVTNP LLYRVIHGRP SIPDRYAGRL IEAGVFDQQD VDAISNSHRN
YLTAELAACE QYEPERSYFG GQWAGLQQPG DEVTVWNTGV DYRLLSHIGQ ESVRLPEGFN
VHPHLQKTHI DARRKRIAEG QRIDWATAEA LAIGSLMYQG FNVRLSGEDV GRGTFAQRHA
MLVDQQTNEI FIPLNAMAAA TPNAGRFELA NSILSEEAVL GFEYGMAIDS PNSLVLWEAQ
FGDFFNGAQI IIDTFLVSGE TKWMVCNGLV MLLPHGYDGA ASEHSSCRVE RFLQMTDSRE
TSPDGDAVNL QIINPSTPAQ YFHALRRQQI RNFRKPLLVV APKTLLRLSD CVSPHTDFAP
GTHFQPVLPD PAPLDPKRVR RVVLCSGKHY YTLASERQAR QVTDVALVRV ESLCPFPVQA
IRDELAKYAN AREFVWSQEE HRNMGAWTFV QPRFENMCER RIQYRGRPEA ATVAVGVSKW
HVREAEDVIK TTLY
//
