ID Q7QHH4_ANOGA Unreviewed; 1347 AA.
AC Q7QHH4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 4.
DT 27-MAR-2024, entry version 150.
DE SubName: Full=AGAP011187-PA {ECO:0000313|EMBL:EAA05150.4};
GN Name=TOLL10 {ECO:0000313|EMBL:EAA05150.4};
GN Synonyms=1270739 {ECO:0000313|EnsemblMetazoa:AGAP011187-PA};
GN ORFNames=AgaP_AGAP011187 {ECO:0000313|EMBL:EAA05150.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA05150.4};
RN [1] {ECO:0000313|EMBL:EAA05150.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05150.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA05150.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05150.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA05150.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05150.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA05150.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05150.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA05150.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA05150.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP011187-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP011187-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AAAB01008816; EAA05150.4; -; Genomic_DNA.
DR RefSeq; XP_309458.4; XM_309458.2.
DR STRING; 7165.Q7QHH4; -.
DR PaxDb; 7165-AGAP011187-PA; -.
DR EnsemblMetazoa; AGAP011187-RA; AGAP011187-PA; AGAP011187.
DR GeneID; 1270739; -.
DR KEGG; aga:AgaP_AGAP011187; -.
DR CTD; 1270739; -.
DR VEuPathDB; VectorBase:AGAP011187; -.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR InParanoid; Q7QHH4; -.
DR OMA; LLWFDYS; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF22; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 23.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 9.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1347
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014588539"
FT TRANSMEM 1027..1051
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1084..1222
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1262..1315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1347 AA; 150873 MW; E1292A6FBE128ACC CRC64;
MQLQQIVTVL LLLGLVTVAV ARSNLMSRMD VAPRGCKWQR VLDETGEEEA PATVTTVLSC
KLKTIGATDT LMRNLSSYQI ERINSLRLEC SDILFFESSL EANQHSGAFL GSLRRLRDLK
IEYCKIKYVP SMVLATLRDL RSLSLRTHNT DWSAMNLEFH PESFRGLTEL KRLDLADNNI
WALPTDVFCP LFSLRHLNLT RNRLTDVSQL GFSDWGNGPT APGKACNTGL EVLDLSHNDL
LALPDNGLSS LRSLSVLMLQ DNLLTALADR SFVGLGSLKV LNMSSNKLVA LPPETFQSTR
ELRQIYLQNN SLSVLAPGML EGLDRLEILD LSHNELTSEW VKRNTFAGMK RLVVLEIAHN
ALTKIDRHVF RELYSLQILN LEANQIESIA DNAFSDLKNL VALTLSHNRL KRIEQHHFSE
LYVLNQLYVE SNLIESMHGR ALENLTNLND LNLNDNRLTE IPEGLGKLRF LKSLDLGKNR
ISAVSNASFE GLEQLLGLRL VENRITNISR DAFVTLSSLH VLNLASNQIR HIDQSAFSSN
PTIRAIRLDN NELEDISGVF TSLPALVFLN VSDNQIRLFD YSHFPVSLEW LDMHQNNITE
LGNYYDLNNL QIKMLDVSFN RLTSVDAKCI PDSIETLFLN NNALEEVAAG TFLSKRSLEK
VVLYGNYLRK LEIGALALTR VADDREVPAF YLGDNPIHCD CTMEWLQGIN KLAHLRQHPR
VMDLDTVLCT MEHERGASIR PLMDLRPHDF LCRYETHCFA TCHCCEFDAC DCKMTCPDRC
SCYHDHTWKA NIVDCGSADY TEVPEHIPMD ASTIYLDGNE LRQLASHQFI GKKKLEVLYL
NGSNIRDVHN RTFNGIPSLR VLHLENNYIN ELRGFEFDQL TNLNELYLDH NAIAYVGERT
FESLRFLEVV SLSDNRISEF RPWQAFAAAG ETGSLARVAL DGNRWRCDCE SLRRMQRWIR
TVSGNFELQR MICADSRVVA DAIASCDSRQ GGGVFGAGAE AGEVDGDGPP AVHRTVLLGH
GLIGGGYVPL LAAILVAIIG TALIVALACV FRQDVRLWAH ARYGVRLVKD PIIVGGRKEP
DSDRLYDCYL VHSVHDSDFV GRLLGAELQL HGYSVCQHHR DVHPGAFLAD SLQSAADSAR
KLLLVVSMNF LQTEWSQPQF RVALQSVIES IRPAHRRHKI VLVLTAPVEI VAMDPIMHLL
IRTCTVACWG ERKFWDKLRY ALPDVPKDRV PAKLGDITRS PANLRYTPAP TSLEQWCKIS
PGETGPNGGQ IVPPGGPVPV AGIPQSTPSQ STCNTEDESS SSASSQHYEA PMSQHYNMSR
SSASLGHVYS TIPETPQMGR NGRAYFV
//
