ID Q7QI51_ANOGA Unreviewed; 397 AA.
AC Q7QI51;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 24-JAN-2024, entry version 105.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN Name=1270387 {ECO:0000313|EnsemblMetazoa:AGAP005295-PA};
GN ORFNames=AgaP_AGAP005295 {ECO:0000313|EMBL:EAA04813.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04813.4};
RN [1] {ECO:0000313|EMBL:EAA04813.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04813.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA04813.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04813.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA04813.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04813.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA04813.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04813.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA04813.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04813.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP005295-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP005295-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; AAAB01008810; EAA04813.4; -; Genomic_DNA.
DR RefSeq; XP_309087.4; XM_309087.4.
DR AlphaFoldDB; Q7QI51; -.
DR STRING; 7165.Q7QI51; -.
DR PaxDb; 7165-AGAP005295-PA; -.
DR EnsemblMetazoa; AGAP005295-RA; AGAP005295-PA; AGAP005295.
DR GeneID; 1270387; -.
DR KEGG; aga:AgaP_AGAP005295; -.
DR VEuPathDB; VectorBase:AGAP005295; -.
DR eggNOG; KOG3941; Eukaryota.
DR HOGENOM; CLU_046917_1_0_1; -.
DR InParanoid; Q7QI51; -.
DR OMA; NMADFGV; -.
DR OrthoDB; 4098911at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IBA:GO_Central.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 245..379
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
FT REGION 27..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 45335 MW; 9ED504C161631B29 CRC64;
MLLTRPLRWS ASVLQLPMAR FSTTLRQCST KRNEETADGK PEDGGGKQGS LIVRTNLFES
AAKKDKQTYI EMVKIFEKRS VHRRNHVEFI YAALRHMEEF GVNKDIAVYK ALIDVMPKGK
FIPTNIFQAE FMHYPRQQQC IIDLLEQMED NGVMPDYEME AMLVNVFGKK GHPVRKYWRM
MYWMPKFKNL SPWLLPNPVP DDALELARLA VERMCSIDPR SKIQVFDTQE VESAIDHTWV
VSGQSGEQSE LLEAHDRQEP VYIEGPFVIW LRNRSINYYV LKSAPKPLPP IEETDDPDDV
SNLHNPYVGL DLRFRKRPGS GSAVSTRRRS VHEQEDGIIY AICCTGSSTK DSLLSWIRLL
EKESGNGALS SLAVLFKFTS PTSEVMVSGA ETSTVQQ
//
