ID Q7QI56_ANOGA Unreviewed; 2265 AA.
AC Q7QI56;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=AGAP005290-PA {ECO:0000313|EMBL:EAA04792.4};
GN Name=1270393 {ECO:0000313|EnsemblMetazoa:AGAP005290-PA};
GN ORFNames=AgaP_AGAP005290 {ECO:0000313|EMBL:EAA04792.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04792.4};
RN [1] {ECO:0000313|EMBL:EAA04792.4, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04792.4,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA04792.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04792.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA04792.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04792.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA04792.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04792.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA04792.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04792.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP005290-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP005290-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AAAB01008810; EAA04792.4; -; Genomic_DNA.
DR RefSeq; XP_309078.4; XM_309078.4.
DR STRING; 7165.Q7QI56; -.
DR PaxDb; 7165-AGAP005290-PA; -.
DR EnsemblMetazoa; AGAP005290-RA; AGAP005290-PA; AGAP005290.
DR GeneID; 1270393; -.
DR KEGG; aga:AgaP_AGAP005290; -.
DR VEuPathDB; VectorBase:AGAP005290; -.
DR eggNOG; KOG1811; Eukaryota.
DR HOGENOM; CLU_230725_0_0_1; -.
DR InParanoid; Q7QI56; -.
DR OMA; VHDNCES; -.
DR OrthoDB; 2945465at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1461..1521
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 530..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2265 AA; 252029 MW; A44A3BF88C6E2B15 CRC64;
MENFNEYWEL FVDKKDSIAK EIIAYYKTLD DYEDGTELSE QCRRFFRKNM IHSPYPTCQL
LKLLAMSKIS AKNSAIYEIA TAAVLDAFEQ HDEQQTDRNK CYNILANSLM SVKAIGNLKA
LLLRALERKA IELEQLMLAL FSRKSVKLMV HLMPELVGPL QQHQAGEVLD KKRHFFGSLL
TASAKSFYVH HTNYIRFIEQ VALANAADGG SFSAAVETVS ALPIAKSYLN AYLLELQRCH
RIQQTLQLDK TLLPAQDFSQ HATVLSMMVR ARTDLNEVDF AKLLAVMRTN QTLHEQITAL
SSEPESGAEN AHDVMALVEL QALFVLYKAI EEEAVASVSQ DAASLITTNN LDAQLKCLFK
ETDMQTFMHA MESIFTMLFV RGELIGNDTN LPERRTFLCS TALLGALTSS IKSIMITRKH
SASYQEADDT LKRRFQTLLD LVIDVCWRLS LFDERPSLEA TLSPTEPANC AQPVRLIDMP
PVPTTLTHIT ETVCESASAS GNAKLFRSVE SIAAIDFAVG QRHRYGYYGT LPKHKSSRRA
NRNPLTATGS SNSGGSNKDL QRQGSLSVDP KSESLAYDRK TTDGGLWSRK HFTKLFATPE
TLAIVCLTND RMSFAKQIID NHSLRDRPVG RLVERIEQMQ ALKADLSALI KKNERKRETA
RGSSGTQSSD SNNDALLDDI RSKTAMGFEI SKVLSTIETF LKSQPVQPGT DASVPVPLDR
FVVRYPFLSG LTGANLHLSQ IVDAVLNLPF SYELNLAIYN FVLKNAHQTT GACHPSTGMM
SSSIAGHGGE TAQLSGNYVS FFGNIIDTLQ LAHKTARASA CRLTIAELLS REVCPLDAVE
NGLVLKRRAR FHGMVERADE LLHPPADDPE RSYALLADSC GVGGSASLAK VKLYLEHLTK
LLQSLLSTGT DRRTGNEPLT TNLNELMQTD AHTVMLERLF AKDVAFATMD QMASMLGINL
VQALGKRLLG PGEEIKPMLH DAPALWEYIA SKSVLLCQLC AIQINGAEAS TNKSLVGNYS
KLMNASDLPF GCSHIRTSKA NAMQACNPFS LDSNRTCCML QAQQDNDHIR SKLLPNEDDV
SMEQKAQALL ANVDQYTVAN EWISASEHLL TAVAKNVTPR QCTIVLATRH KLQQTANELR
TYLRVGTILQ LASPDEGGAE GAGWQRARKF SAENKSTVLH QLIELGELRV CADWIKLHPI
EAERELEMFM YAVHKLSAAS TVAVIPTTTT ILEPDSEPPI ALLFRIIETM PVEAVVKLYE
TIMLNIRSVP VVSYMLGYLE RNTTTKPLYQ KYQLSLKIFE HLSHDEYEGL WNLASRPLLI
VEQCLMNSRL ELLAGVMRSI RGLLVADVCT HCYEHREYIR DLHDAVQSGT EREQQPQTST
VLRHYPVHDG LFISHECVDC LLRVYAGKAL EYKVFPDVVG PADTLPDGPV SRVSSYDSLS
EVGQPFVMPK DIPGRDRWVK DEEALHCMCC RRTFSMLNRR HHCRRCGRVV CHSCSKRKLR
LQSFYEDVAV RVCDDCWRNL AGTKDTTAVA AAAVPSAAVS QSRTSDTGSQ YEWQLTGNER
YDNVIRDEYS YEYAPSTSQC LAICNLHTPN EEMASFLLYH CAKLEALLRP LHPGVPNPEI
DYALVARMLL NLTLGVKVRG GGAEVEKMKE HAEIILSIVH DNCESLLLDS PSMSNHGSLR
KLRDALVKAE KWTLALELSL KCGFSLNGVM AAWGMACLRA GCYETAREKF SHCLPRVASE
AECEAVLRMI EAPRAGIATV VPIVKRPARC PPLLNEIVYA LAYTARLGAP SERVTARVNA
ARHASAGSGA VGAAHEPALN ILSTLANLRN VCQGEFDGDV PGPNAERLAR HDAASIVLCS
RLFEESMHYL LAYGSHASVV QFLMRYAQTE VAALRYILAQ RVEPDVFLQT VLLPYLQHGE
LETIVQRLSD IDDTLLEWRE YIRYACRYLE TNDMLNSLYS LQLLLKDPIR ASMTCVRFYT
TGCRTFADLQ AAEHHLKTSV THLQNELELC NWQEVRLNST GTAIETHHSL LMKLDPKELN
NHINTILLQL DVTKFLATCE TKGRQTVALL PKIFREASQL PTLFGGSHDK LQLAILTLVC
GQNVEEAFGL SYRIIQDYNL DMQRVYALTA KYFINHGKIE DVGKLLDAIV SNECSSSTTS
ATTEPAVSAI CDEIVRVSVD VAISRHGTGV NTKVALETLI NRASSVAVRI HCYIVSGQLK
AAYLLANRHQ RTGDIRKILR QAELLGQMHV KRLCEARLSH QESNP
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