ID Q7QJI4_ANOGA Unreviewed; 965 AA.
AC Q7QJI4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 113.
DE RecName: Full=Vinculin {ECO:0000256|ARBA:ARBA00014125};
GN Name=1269702 {ECO:0000313|EnsemblMetazoa:AGAP007532-PA};
GN ORFNames=AgaP_AGAP007532 {ECO:0000313|EMBL:EAA04738.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA04738.1};
RN [1] {ECO:0000313|EMBL:EAA04738.1, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04738.1,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA04738.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04738.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA04738.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04738.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA04738.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04738.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA04738.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA04738.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP007532-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP007532-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR EMBL; AAAB01008807; EAA04738.1; -; Genomic_DNA.
DR RefSeq; XP_308347.1; XM_308347.3.
DR AlphaFoldDB; Q7QJI4; -.
DR SMR; Q7QJI4; -.
DR STRING; 7165.Q7QJI4; -.
DR PaxDb; 7165-AGAP007532-PA; -.
DR EnsemblMetazoa; AGAP007532-RA; AGAP007532-PA; AGAP007532.
DR GeneID; 1269702; -.
DR KEGG; aga:AgaP_AGAP007532; -.
DR VEuPathDB; VectorBase:AGAP007532; -.
DR eggNOG; KOG3681; Eukaryota.
DR HOGENOM; CLU_012338_0_0_1; -.
DR InParanoid; Q7QJI4; -.
DR OMA; ANNLCEL; -.
DR OrthoDB; 2908505at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044291; C:cell-cell contact zone; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045294; F:alpha-catenin binding; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.120.810; Vinculin, Vh2 four-helix bundle; 1.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR017997; Vinculin.
DR InterPro; IPR006077; Vinculin/catenin.
DR InterPro; IPR000633; Vinculin_CS.
DR PANTHER; PTHR46180; VINCULIN; 1.
DR PANTHER; PTHR46180:SF1; VINCULIN; 1.
DR Pfam; PF01044; Vinculin; 1.
DR PRINTS; PR00806; VINCULIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 6.
DR PROSITE; PS00664; VINCULIN_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 744..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..773
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 106808 MW; 3DA8463B97EFBF00 CRC64;
MPVFHTKTIE SILEPVAQQV SRLVILHEEA EDGNAMPDLG KPVQAVSVAV TNLVRVGRET
IQNSDDDILK QDMPASLTRV ETAAQLLEEA SLMLRSDPFS GPARKKLIEG SRGILQGTSS
LLLCFDESEV RKIVRECKRV LDYLAVSEVI DSMEDLVQFL KDLSPCLSKV TAQVGAREKE
LTHQVHSEIL VRCLEQLKIL APILICSMKV YILIAEQSGK GSEEAAENRN YLASRMSEEL
QEIIRVLQLT TYDEDQSELD NLTVLKKIQN AIRNKLEAAN EWLRNPYALR GGVGEKALRQ
IVENGLKVAD RCLPQDSHIL RKLAGDITAM TNTLCDLRQE GKGTTPHADN IARDIRDKLG
SLDQSVLNAI MGVDKAGLQQ TAHTVQGRLE QACRWLQNPA RDDRGLGVRA IALIVDEGRR
VADGLGGHQK AEMAQLCDEV EQLAHDFSQM CNNGLGHTPQ AQELARRLNE KLHGLKKQIQ
DAVVNRVVED FIDISTPLKQ FMEAVAQPEG TPGREQNFNQ KSNRLQAFSN RASKTSRMVA
AGGSGGNKKL AEGLLASANQ IDSLTPQLVS AGRIRMNYPT SKAAEEHLNN LKQQYADTIL
RMRTLCDQAT DPADFIEASE KQMQKHSFLC DDAIRTRQPQ KMVDNTSSEA RLANRVLLVA
KQEADNSEDP EYIDRLNGAS DQLQASISPM VQEAKNVSTN ISDPIAASNW REANRALLQS
VRNVRGAVTH APTVPEMPDL SQLQLGGGSH EVVPPPRPPL PRENVPPMRP PPPVAETDDE
DDVFQAGSMP HANQPILMAA HGLHQEVRQW SSKDNEIIAA AKRMAVLMAR LSELVRADSK
GSKRELIATA KQIAEASEDV TRLAKQLARQ CTDKRIRTNL LQVCERIPTI GTQLKILSTV
KATMLGAQGS EEDREATEML VGNAQNLMQS VKETVRAAEG ASIKIRSDQT NQRLRWVRRQ
PWYQY
//
