ID Q7QJR3_ANOGA Unreviewed; 1462 AA.
AC Q7QJR3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 4.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=AGAP007623-PA {ECO:0000313|EMBL:EAA03965.4};
GN ORFNames=AgaP_AGAP007623 {ECO:0000313|EMBL:EAA03965.4};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA03965.4};
RN [1] {ECO:0000313|EMBL:EAA03965.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03965.4};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA03965.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03965.4};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA03965.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03965.4};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA03965.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03965.4};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA03965.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03965.4};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA03965.4}.
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DR EMBL; AAAB01008807; EAA03965.4; -; Genomic_DNA.
DR RefSeq; XP_308248.4; XM_308248.4.
DR STRING; 7165.Q7QJR3; -.
DR PaxDb; 7165-AGAP007623-PA; -.
DR GeneID; 1269605; -.
DR KEGG; aga:AgaP_AGAP007623; -.
DR VEuPathDB; VectorBase:AGAP007623; -.
DR eggNOG; KOG2956; Eukaryota.
DR HOGENOM; CLU_005060_0_0_1; -.
DR OMA; LMEHKVQ; -.
DR OrthoDB; 5478662at2759; -.
DR PhylomeDB; Q7QJR3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProt.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:UniProt.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 317..548
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 817..1060
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1213..1449
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1386..1424
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 606..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 162390 MW; CB80510C33A72A4D CRC64;
MAYQKPIDID GYVTQMAKAD MRVKAQLAED LVLYLSDSEN SIECTDLGLL IDGLIPWMTG
SHHKIAQRAL EAFTELIVRL GQDFNAYTST ILPHVIDRLG DSRDTVREKA QLLLHKLMEC
RVVVPQSLLD KLSVCFKHKN AKVREEFLQT IVSTLNEYGT QSLSVKMYIP PIVSLLGDPA
PTVRDAAIQT LVEIYKHVGD KLRVDLKKRE VPPTKMAILE QKFDETRNDG LLLPSALQAA
PTAAGGGGHD ELDRAAVVER PTRLVKRTPS ATPRKPLFET QTAGSGDLLL AAGAVSAEVF
EASFENVPQL TIFSQRDMDE HMKSINTLIG DNRVDWEKRV EALKKIRSLL MINVQGSPAF
VQQLKDLSIA FLDILKELRS QVIREACITL AYMSKVLRNR LDQFTIYILQ ELINLIQNSA
KVISSAGTIA LKYVIRYTHA PKIIPILTQN LMLSKSKDIR STLCEMLGLL FEEWPTKTLE
KHNSLLREAL RKGMVDADND ARRHSRCAFW SFRRHFPDLA DNLYGSLDIS TQRALERERD
NLGTNGTNSM SVSLRGSNSS LNSVSGGVIS MSAGGFRSVS AVDTAAAQRA RARAQYSTLA
RLKVTSGTAS LPRAKKTPSS ASATSSSASN TATPQQPPTP ERKIRSRAGV SQSQPTSRST
SPSSKLRDMY SGVTSIYRQT GTVPKKAQSG IPRSLANSRE TSPTRTHTQF GSLRRTAYGT
SSPRRPPLNP GRPVLAQKIL QQSREAENAL ADALSPGDEH DMPCSDFARL ALHRKISRDE
SDESEASSVC SERSYDSYRR GNDVSSFSWN GSRTRLDSSR QVIDDIDTII QFCASSHWSE
RKDGLINLTQ YLSEGKMLTQ QQLQCVLDLF RKMFMDPHIK VYALFLDTVN ELILSHSNDL
QDWLFILLTR LFNKLGTDLL GSMHGKIWKT LQLIYEYFPA DLQLQCVFRI LVDNAQTPNV
KTRQATLKFL SQLATSYCTA SQFVVHPQNQ QVVNLAIQKI IQTSLDQKSI ELKSQARMCI
VALYNCNPSQ MTMALANLPK QYQDTAKIYI QQNMRRSTSG NDSPSSPLSS SSPKPLLSPQ
QGPYSLQNIA SPRSRQASVE AAAESMNTEE VYKNLRKTTA EIQNYSFESK LDRDANSKDS
GISQMGETHM MQSMTDDSCN GSKTQSATTT ESNTPENTVR LDGMDLAHKT IAQQQQMLQQ
QRHQSYSRAE NGELILDKGV KENDVIKAAI VLTLQSAPET TKQVLENLQI CIKHGSCDLP
IKNFKAIMKM LLHLMESQNN DVLIASLHTL GRIVRSTEMK ACWSNFLELI LLKIIDCYKI
SKEVSREIDI IVVKIAGILP LDISVNILNP VIATGEFPAN LCALKILTEL TQKQGKDLTD
NHLDCIMPNV ARLADDSQSM VRKAAVFCIV KLYIVMGEEK VKPKFSLLNA SKIRLLNVYI
AKSMGSGSSS SSKGGSSTTA MS
//
