ID Q7QK93_ANOGA Unreviewed; 1289 AA.
AC Q7QK93;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE SubName: Full=AGAP002223-PA {ECO:0000313|EMBL:EAA03817.1};
GN Name=1269336 {ECO:0000313|EnsemblMetazoa:AGAP002223-PA};
GN ORFNames=AgaP_AGAP002223 {ECO:0000313|EMBL:EAA03817.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EAA03817.1};
RN [1] {ECO:0000313|EMBL:EAA03817.1, ECO:0000313|Proteomes:UP000007062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03817.1,
RC ECO:0000313|Proteomes:UP000007062};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EAA03817.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03817.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EAA03817.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03817.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EAA03817.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03817.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EAA03817.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EAA03817.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EnsemblMetazoa:AGAP002223-PA}
RP IDENTIFICATION.
RC STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP002223-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
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DR EMBL; AAAB01008799; EAA03817.1; -; Genomic_DNA.
DR RefSeq; XP_307960.1; XM_307960.1.
DR STRING; 7165.Q7QK93; -.
DR PaxDb; 7165-AGAP002223-PA; -.
DR EnsemblMetazoa; AGAP002223-RA; AGAP002223-PA; AGAP002223.
DR GeneID; 1269336; -.
DR KEGG; aga:AgaP_AGAP002223; -.
DR VEuPathDB; VectorBase:AGAP002223; -.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_001832_4_1_1; -.
DR InParanoid; Q7QK93; -.
DR OMA; PERVYVQ; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 107..152
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 244..271
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 462..636
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 733..914
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT ZN_FING 244..271
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 269..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 218..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 402..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1289 AA; 146636 MW; 20B21DC88FA7B1D3 CRC64;
MDGESQQLIS DCFLRTIVDP RSTNAPIEPP PTKQPVKVEL QVLRLKDESQ TLIMDTLRSI
HGESFQLGDI SKYEDKGGRM KKGFWQDRGN LVIQGGFDYS NIPRTGNSNE DKFRMYAVMK
LHSYAFHRSH CEEALDHHNG DVDKALALLF SKYFPPPNDL PPVAEDHNED ELDTLRADER
EALESIYDKL FVEKEHNRVW QLKFKIDHLL THSPSEMKKQ AEREAQQAEE EKRRMLEALA
KKKKAKREKC WNFAKGKCRY GNRCHYSHEL DEPKDESDKK PGKRGTDKAA DEDPNWFYLE
IRFPPGNRYP FERPILLLKT TCSDIPEQLC LRVNRRLVQE CIELTKDGMP CIYTVADLLQ
NDEEIGRFIE QDRYQFPDGR RSLFYVPEQD ADDGGSGENL PTHHQRGVTG RQTGPKLNPD
QLMKEDRNIV RKFMDKQTNA AYKEMLKNRR NLPAWTKMSE IVALMEAHQI LVISGETGCG
KSTQVPQFLL DDWLLQSSKL KPNEPLRHVE IICTQPRRLS AIGVAERVAD ERNEKIGNTV
GYQIRLENKI SSSTRLTFCT TGILLRRLQS DPTLATVTHI IVDEVHERSE ESDFLLLILK
ELLTKRTDLK VILMSATLNS NLFASYFGDI PVLDIPGRTF PVEQLFLEDI LERSGFVLEP
DSQFCRKLRK GEQELLLQEL EYSDVKAANA APAKTIRDEN LKMADMFARY ADYSKQTCKA
LYLMDPLRIN PELIEHVLTY IVDDTSHGWP REGSILIFLP GLAEIQTVHE SLAESKLFGP
RGDRFVLIPL HSMLTNEEQA LVFRKPPKGK RKIVLSTNIA ETSVTIDDCV FVLDCGQMKE
KRFDSNRNME SLEMVWVSRA NALQRKGRAG RVMPGVCIHL YTRPRFTHHI LGQPVPEIHR
IPLEPLLLRI KTLPTLAERA LNEVLGAIIE PPSVENIQAA KKRLIDVGAL DLEEQLTPLG
HHLSALPVDV RIGKLMLFGA IFQCLDSVLT MAAILSYKSP FVSPFGKRDE ADNRKRQFAI
ANSDHLTMLS AYRRWLEAAQ KSRYAGQCFA EENYLSGKTL ATIGEMKYQF LELLVSIGFV
PIDLSGRSRA KRQQLDDLLK LTGAEINVNG TNNRLLAAIL CAALYPNVVK ILTPEKSFVT
GAVGAVPRLP QASDLRFKTQ EDGYVALHPS SVNATVGYFG SPFLVYQEKM KTSRIFIRET
TMVPLLPMVL FSGSDLAIEL HGGDFVILLE GGWLMLQAAT HQIAEMVKFL RLELAKMLEL
KISDPLLNLM NHEHGKRVID TIVRLISKE
//
