ID Q7RJK4_PLAYO Unreviewed; 2594 AA.
AC Q7RJK4;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=PY03255 {ECO:0000313|EMBL:EAA22812.1};
OS Plasmodium yoelii yoelii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=73239 {ECO:0000313|EMBL:EAA22812.1, ECO:0000313|Proteomes:UP000008553};
RN [1] {ECO:0000313|EMBL:EAA22812.1, ECO:0000313|Proteomes:UP000008553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17XNL {ECO:0000313|EMBL:EAA22812.1,
RC ECO:0000313|Proteomes:UP000008553};
RX PubMed=12368865; DOI=10.1038/nature01099;
RA Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C.,
RA Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M.,
RA Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E.,
RA Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M.,
RA Shoaibi A., Cummings L.M., Florens L., Yates J.R., Raine J.D., Sinden R.E.,
RA Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W., Vaidya A.B.,
RA van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R.,
RA Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J.,
RA Carucci D.J.;
RT "Genome sequence and comparative analysis of the model rodent malaria
RT parasite Plasmodium yoelii yoelii.";
RL Nature 419:512-519(2002).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAA22812.1}.
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DR EMBL; AABL01000925; EAA22812.1; -; Genomic_DNA.
DR STRING; 73239.Q7RJK4; -.
DR PaxDb; 73239-Q7RJK4; -.
DR EnsemblProtists; EAA22812; EAA22812; EAA22812.
DR InParanoid; Q7RJK4; -.
DR OMA; MGRSIDM; -.
DR Proteomes; UP000008553; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 2.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008553};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 524..828
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 220..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1738..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2102..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1738..1764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2106..2171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2189
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2199..2239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2240..2255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2256..2300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2594 AA; 300899 MW; D3349FF1BBAAD7C3 CRC64;
MYDINSANCS EIKSAELGVL SSQELKRISL GKYENQLQEF EKVSKDGTSN RITYDPRFGT
IDYTQICSVC FEKHDSCLGH IGHIEFVLPV FNPLFYKDLQ ELLNLVCYNC YALCYSEDVI
FLLKHIYQLK SLNEIESSNK FIIKKNNENE YIVSEIERLY NKICKESNIT MEDIVESICQ
DYENSFGNNE KDNNENDSFE DRQTYELWKK INDDIYNDDQ TNEADFSKES DNKKKHNYSK
DKKTNQEIEN KETKEKIKFL KEKIKKYKFD ISKLAFQSNY NYEEYVILNK AIKLHMKKGA
NCSNCKFRRS IVAKTSPKKD TINFVGIYTN NSFFKKYISK KSKNEGFEEN GNNSNDDNDD
DAEVGKANKR GKEIKSEKIK NLNNSENGID KFQYEGSNNK DGDEEDESFK DAVASYKRKT
SREKCTVRLF SFQIIDLLKK IFVENNKEII NLVYPFTKKD GYQVFFLYYM GISSNRFRTQ
SRGIHKRTRI TNYICKLNNY VKLCINSKKN VDFDHMIEYN KNELDLYNEM FLLFSLRLRQ
RVISNSMEFN IEIAKSDFLR CYSLIYNNKI AYLNILFGNL QLSVNTFLDS SLIDKRLQKN
MDNISIREIL DKKEGILRKN IMGKRVNNCA RTVISPDTFI ETNQIGVPIE FAKTLTIDEH
ITENNFEYVK KLIENGPDVY PGALSYKDGQ GRVFKLSHSY ENRMNLISRL THILQKGKHE
TLVLHRHARD GDIVIMNRQP TLHKFSIMAH FLKIFEKEKV FRLNYVNCSS YNADFDGDEM
NLHLLQTPLA RAEATHLMNS DFLFTSFKDG SPLRGLAQDF ILGGLHLTSL ETFLNYDEYC
NLLQCSLNGL LRQKNAFFFS KTKHRNTSNS SNTKDGNKNS GGNDKSGSNS FRGINAKISN
YSYIDPYATN LNKTNFTIKT EEPTILFPKK LWTGKQLISS ILKTIINELA IETYNKNGDN
SFMENFKGIN YVAKAKTDPE LWSFDPKKEC EIIIKNSELL QGVLDKLHFG ASSNSFVHLC
YELFGPKSAA VMLDCFGRLF ISFLQLRGTS LSLYDFILKK KAKVEKKKIK KRISFTGFYL
QNLFVYTIGK ALNADMNKMD EYSNKKISNY EEGQNLFSNK LYDIYLNKSQ IINKYERKLE
KKMNIEDKHM NTNICLTKKN IPNKFNLFND KELNLKKDLY FITFLNKEIE EIFTQNNMLS
GNVKNEESEE TQKCKYSDSP HLNYIIKKEN YEIFEKCLVG KNKLNSLEKQ GKDGTICEGG
TIWEDESRYY EFVNSIINKL YNSINNPIFY KTSTFTSTQV VKVIEKIVNF LKEAKCNKKL
KVFILFELFQ NENIVKYFPS LIDFASGLNT NISSEEIVET VINNILLKKD LKLETEYVSS
LNTEKIKFND NKLEKTNDVI LKKYLHLYSR LIKIEREKKG KINNNSPSKL KHDEDEINET
KFENSQNIGI DNVDIIKNCL ISSLPSFALN EDITNLSYNN RYQYYEKYLN IKDEKYSHFK
FYRMKDVFHK LDFLINNFFS LKRINFDGLL DSLFQPYLCR VSSGTNNLIT MENLMNKFLT
NGFSNMIFTG AKGSKVNYSM ICGMLDQQYL EGKRVPRMRS GKTLPSFHRY DYGARSCGLI
TDCFLEGLRP QEYFFHCMSG REGLIDTAVK TAKSGYIQRC LIKSMESVIL HYDGTVRNED
NSIIQFLYGE DGIDPSKTAY LNLPSDLINN YNISFSKYLN YGSDQLILSN QRLFAKNDGK
KKNEDGKKNE KNGENGKNGK NDDDDGDGDG GEDDPLIFQY NPYTYIGSIS DNYNAKLNNI
LINKKFNITN YNENFDSLSA SLLRSKYFHS LCSPGESIGI LVAQSFGEPA TQMTLNTFHL
AGTENVTMGI PRLKEIFLTS KLTSKPMIYV PIKLDEKNNN NPNQIKNYIT NIADKILSSY
QSILLSEVIY GIGINRKLII RDKIENKEIH TIKLDNNLLS KNNKENESNW DKSDICKTAN
YSKILQVIEN TNLNFDLKKE WVHEIVIQFD NLNHFCKVNK HLSIPFILYK MVNIVLMSIL
NKIQNSISHH NIKNIHFINH EHYDELFDFI SEKMSEEFNF AYEKYEYKDD EDEINAKLKY
MPNKSEGNKL GDDDDHYNTS LKTPKKFSED NDDNFSMDGK NEGSDNDKND KSDGNNDSDQ
NDGRESDEYK SEQEDKEYDE SEEDAENDTD SMLSQNAADT DDDIKHENVN SSESDDGDEK
KKEKKSEKKE KKKSKLLNET DSESNYSSDE SITDSSIINE DPKESNKSKK EDKLNTSSKK
RKLTDVNDNI KNEQNKNKSK EINSDSSISS ESETELKQKM SKKFSEYLYD YKNRMNKHNL
DVSDYEDPSI GISGSKNKLN DQKYIKNLID KIKSSLLCFI KKIDFSPITW VLKFELSWDV
NFFPYPIDFL SYLQNEISKE ILFKVKDLNN PKILKGKDIT HSGEEYELQI EGRNVYKLFN
IKDKYIDKTK LYCNDIYTIV KTYGIEAGRL CITKELKKVF EAYGIKIDFR HLSFISDFMT
HTGDLKSFNR YGMAACRNVF HKMSFECATT FMIQGCIQNS VDYLSTPSSS LFFGKHIKVG
TNVSNIVTSI KAGK
//
