ID Q7S075_NEUCR Unreviewed; 484 AA.
AC Q7S075;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 08-NOV-2023, entry version 85.
DE SubName: Full=G-protein coupled receptor {ECO:0000313|EMBL:EAA28708.1};
GN Name=gpr-2 {ECO:0000313|EMBL:EAA28708.1};
GN ORFNames=NCU04626 {ECO:0000313|EMBL:EAA28708.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA28708.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA28708.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM002240; EAA28708.1; -; Genomic_DNA.
DR RefSeq; XP_957944.1; XM_952851.2.
DR AlphaFoldDB; Q7S075; -.
DR STRING; 367110.Q7S075; -.
DR PaxDb; 5141-EFNCRP00000005931; -.
DR EnsemblFungi; EAA28708; EAA28708; NCU04626.
DR GeneID; 3874091; -.
DR KEGG; ncr:NCU04626; -.
DR VEuPathDB; FungiDB:NCU04626; -.
DR HOGENOM; CLU_024810_3_1_1; -.
DR InParanoid; Q7S075; -.
DR OMA; RMEIPYL; -.
DR OrthoDB; 2718660at2759; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR23112; G PROTEIN-COUPLED RECEPTOR 157-RELATED; 1.
DR PANTHER; PTHR23112:SF22; G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF05462; Dicty_CAR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EAA28708.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..206
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 407..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 53413 MW; F1ED90773047D591 CRC64;
MSSTMASDDN IDWAAQSPGI HDTINMIERI CSIPSVIGCV FIITTFCLSE RFQKPINRLA
FFATFGNLAT NVATLMGRDY VSNPTGAGCQ MQGFLIQMFM PADAFWVLAM AINVYLIFER
QYDAQKLRAM EKWYFLGCYG LTFVVALAFC FIESPKKGKM YGNATLWCWV SPKWDIFRIA
TFYGPVWVSI GFTFFIYIRA GRDIYRNHKQ IKKFNITSSL AGGPVEDTLV SRKVTEVYIT
HEIATGNAIA LADLERNNGA QEHSGNSAAQ RAPSNAYSVT ISADNQKVPE ATDGDNLARI
TTTTVTGGVS GSANNTRTKN KHNSAMWHYS KCSLFFFTAL LVTWIPSSCN RVYSVVHHNQ
TVKVLEYMGA GVLPLQGFWN ALIYAVTSWK ACQGFFGEDV KGWFSRDTDS GDSQRREGGG
HHRSSSKTIN GQAASGKANP FHKMGGRTAH PCPETESTEE LAACGSRRTS YGGGTDSIPS
KDMK
//
