ID Q7S0Q5_NEUCR Unreviewed; 2257 AA.
AC Q7S0Q5;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=Polyketide synthase 1 {ECO:0000313|EMBL:EAA28899.3};
GN Name=pks-1 {ECO:0000313|EMBL:EAA28899.3};
GN ORFNames=NCU06013 {ECO:0000313|EMBL:EAA28899.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA28899.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA28899.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002241; EAA28899.3; -; Genomic_DNA.
DR RefSeq; XP_958135.3; XM_953042.3.
DR STRING; 367110.Q7S0Q5; -.
DR PaxDb; 5141-EFNCRP00000001401; -.
DR EnsemblFungi; EAA28899; EAA28899; NCU06013.
DR GeneID; 3874282; -.
DR KEGG; ncr:NCU06013; -.
DR VEuPathDB; FungiDB:NCU06013; -.
DR HOGENOM; CLU_000022_31_0_1; -.
DR InParanoid; Q7S0Q5; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IBA:GO_Central.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF13; POLYKETIDE SYNTHASE 1; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 78..502
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2175..2252
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 46..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2257 AA; 245090 MW; D18CE44413D06157 CRC64;
MAPIAVTPDS STASPSGDSW NSYFHVRNGD SHNIISNKGH DHGENALSAA VGNDHGSWTA
EPGIGLSSPL PPPGHVRDMP IAIVGMACRM PGNVSTPAEF WELCTRARSG WSETPKQRFN
SARFHHPNQG KGGTLNPVGG NFLNVDLAAF DAPFFGLTEK EAISMDPQQR LLLECTFEAL
ENAGIPKHTI AGKDVGVFVG GSFPEYESHL FRDPDTIPMH QATGCAYAMQ SNRISHFFDL
RGPSFTADTA CSSSMVAIHL ACQSLRTGES SAALVGGCHL NMLPEFWISF STCRLLSDAG
RSFSFDNRGT GFGRGEGCGM IVLKPLDQAI KDKDPIRAVI AATGLNQDGK TPGITVPHGP
AQEDLIRKVY GRAGLDPNLC GFVEAHGTGT RVGDPIEATA IHNVLGQERS PRNPLWIGSV
KSNIGHLEGA SGIAGVIKAA LMLERGFILP NHDFKQPNPR IPWKEWNLEV PVTQRPWPRG
KKYISVNNFG FGGTNGHVVL TAAPFLRSRT SGSSHDDTLM ASDKSGLGRK LYVVTAHDKA
ALSQQMKNIV VYLEQRPEIF QVDLTSNLAY TLGQRRSLLQ WRAAIPAINS FELIEAINGE
KAITGKEIEP LRLGFIFTGQ GAQWYAMGRE LYEQYPTFSA SILQADACLI AFGAEWSLVE
ELGRDAKTSG ISEAHISQPS CTAVQLALVN LLRGWGLRPT AVAGHSSGEI AAAYAAGIIE
FESAMAIAYH RGRLIPILKT KYPELQGRMM AVGGSKKEFT TLIEGLQAKE VRIACYNSPS
SLTISGDEPA LAELERICEK RQLFNRRLVV DVAYHSHHMN LVAKDYRASI ANLQPPARTD
VQFHSSLYGH PVDSTDLQPN YWVDNLTCPV RFNEALQSML APVGEHKHGV NMLVELGPHS
VLQGPVKQIL KEVGGSAPKI PYASVLVRKR NAVETALELA AQLFTRGANL DLGAVNFPKT
TKPPTLLTDL PRYPWNHSIR YWQESRMTDV HKNAVGSRSD IIGTLASYSS DLEPTWRNIV
RLDDLPWLRH HKIQSLIMYP MSAFLAMAVE AASQRARSKH CSFDRFQMRD IAIKKPLAIP
DNDIEVTISL RPHQEGIFVS SETWDEFRVC SWSSGQGWIE HCVGLIATVK ITENDVVQGP
QTDDGFEDHL HSVVPTIDNA QWASIDPQHM YETLNKLGVV YGPTFQGLDN INVCDTQSTG
DLVAPDVAKE MPGGYLTKAV IQPAFLESLI GMYWPVLGAG RRQVDTIYLP SAIEYVTISR
RITQLASEPG NTLRAICKGE VDPGIHRPFK VHMVAAPAGS LESIIAINGL TVSPVLNDDT
REKNNTPRDL CYKLEWEHIL EPEHVRNQLP VGAQIVIIHE DSNFQLLVAL RLANALEQAT
GRLPEVGKLD TVDAKGKTCI FLNELHRPLL ATLSPWQFSS LQKLLTGVEA ILWVVKGAYD
KCTEPEAYMV TGLSRSIRSE TALRFATLDL DAASPLSEAK AAEMVFCVFN MAFGSASSSM
SELEFMERGG SLFTPRITHD RETDQEVQTL TNPRALEPTA FGDDGRLLRL EISAPGALHT
LHFVDDHSLE VPLAIDQLEI EVKAVGLSFR DAMAAKGQIP ITMSGAEASG IVVAVGSSIS
AFKVGDRVAA LTQGAFATRT RATASLAIKV PGHISFEAAA TLPLGYCVAY YSLVDVGRLA
EGETVLIHQA AGAVGQAAIC LAQMIGAEIF ATVGSAEKKE LLINEFSLPS DHVLYSRDTS
FGPTIRRATY GKGVDVILNS LVGDGLRESW KSLSKFGRLV DIGKRDSASK SRTEVSAAKR
NASFVSVDIF ALLAERPKAL KRVFADVARL LRYGKVRSAS PLSVFPVSDI EGALKMQQSG
SPTMGKAVVA LSGSDFVKAP PSRRLKDLLH SDATYILVGG TGGLGRSIAR WMAGKGAQNI
VLVSRSASVT GKVKELAEDL SMMGVSVHVR RCNVVNETEV DELIRTGLQG LPPIRGIVLG
TMVLHDVLFE KMTWTDYTEV IKGKVQGGWN FHRALLTSPL DFFVAISSAA SAVGNRGQAA
YSAANCFLNS LVQYRLTLGL PASSLDLTAV SDSGYLAEDP EKAAEVARNL GSDTICEAEV
LALLHAAISG KLTLACNNHT ITGMRITSTM RPFWTDDAKF KTMRMAAEDE AARNASLNMV
VSFSATLKNA KSLIEAEDVV CKGLVEKISS VLMLDAEDMD ITRSLSHYPL DSLVAIEIRN
FITRDFEANL QVLELLSSGS IQTLAKAVCA KSKIVSF
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