ID Q7S4I8_NEUCR Unreviewed; 466 AA.
AC Q7S4I8;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Arginosuccinase {ECO:0000256|ARBA:ARBA00032749};
GN Name=arg-10 {ECO:0000313|EMBL:EAA30418.1};
GN ORFNames=NCU08162 {ECO:0000313|EMBL:EAA30418.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA30418.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA30418.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR EMBL; CM002242; EAA30418.1; -; Genomic_DNA.
DR RefSeq; XP_959654.1; XM_954561.2.
DR AlphaFoldDB; Q7S4I8; -.
DR STRING; 367110.Q7S4I8; -.
DR PaxDb; 5141-EFNCRP00000008322; -.
DR EnsemblFungi; EAA30418; EAA30418; NCU08162.
DR GeneID; 3875810; -.
DR KEGG; ncr:NCU08162; -.
DR VEuPathDB; FungiDB:NCU08162; -.
DR HOGENOM; CLU_027272_2_1_1; -.
DR InParanoid; Q7S4I8; -.
DR OMA; DFAIEFC; -.
DR OrthoDB; 2722228at2759; -.
DR UniPathway; UPA00068; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EAA30418.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 15..311
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 373..441
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 466 AA; 52330 MW; 554C4CB1C984FC7E CRC64;
MSGQAKPTEN MLWGGRFTGG LDPLMVQYNE SIHFDRALFA QDITGSIAFA RANAKAGIIT
QDEFNKLEQG LLAVKKEWED GTFKIVPGVD EDIHTANERR LGEIIGKDVA GKLHTGRSRN
EQVATDMRMW LRDELRKIEK HLQDFLNVTA ARAEQEIDVI MPGYTHLQRA QPVRWSHWML
SYGFAFASDL ERLREVIKRV NRSALGCGAL AGNPFGIDRE MMSKELGFDG LLWNSMGAVA
DRDFVAETLQ WGSMLMQHIS RWSEDLIIYS TSEFGFVRLA DAYSTGSSLM PQKKNPDSLE
LLRGKAGRAF GHMAGFMMTQ KGIPSTYNKD LQESWEPMLD HVKTVSDSIQ IANGVLATLS
IQPEKMKESL DPFMLATDLA DYLVRKGVPF RETHHISGRC VALSEQTGIP MDKLSYEQLK
GIDARFEEDI SKVFDYEKSV EMRSAKGGTS KACVQEQIQV LKSMIA
//
