ID Q7S844_NEUCR Unreviewed; 698 AA.
AC Q7S844;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 3.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN ORFNames=NCU06573 {ECO:0000313|EMBL:EAA32507.3};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32507.3, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA32507.3, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; CM002239; EAA32507.3; -; Genomic_DNA.
DR RefSeq; XP_961743.3; XM_956650.3.
DR AlphaFoldDB; Q7S844; -.
DR SMR; Q7S844; -.
DR ESTHER; neucr-NCU06573.1; Fungal_carboxylesterase_lipase.
DR PaxDb; 5141-EFNCRP00000006284; -.
DR EnsemblFungi; EAA32507; EAA32507; NCU06573.
DR GeneID; 3877891; -.
DR KEGG; ncr:NCU06573; -.
DR VEuPathDB; FungiDB:NCU06573; -.
DR HOGENOM; CLU_006586_15_1_1; -.
DR InParanoid; Q7S844; -.
DR OrthoDB; 1743223at2759; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF423; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 181..525
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
SQ SEQUENCE 698 AA; 75193 MW; D612A39D31FDA005 CRC64;
MARIPLKTLA LLWRLPCNSH TSRTTPTLRQ ATEKLAFLGQ NRIRIPVVRL RRGVKKCLTL
EVGADWGSPT LDNKDSAGMI KLFSETASRY PHGPIWPWIS RYFASMPVLQ EFGSGLFANT
TFTHFTSSIP HFYATSNCDP GIMRVVCLSY VWLASILGLG FRGGVAPAIA SFASCVDQSD
LSVTVLGGVV HGIVNETEDA CVRQFLGIPF AQPPVGDLRF APPQPAEPFG DLDAKKLPPS
CIQYLSTSPP SIYTQYLNEY NVQGLNTTSP DISEDCLTLS IWAPPTTTDD SLPVIVFVYG
GAFSTGGQDV PVQIPTDWVQ RTKSHIVVTF NYRLNIFGFP NALGIPLDEQ NVGLLDQRLA
VEWVQDNIEA FGGDPTRITL WGQSAGAVSA GYFQYAYPTD PIVNAVIMDS GSELTPVAQN
LDFAHFGFTR IAGQVGCGNL TAAEELACMR SDSVTAEAIN KAVQTTNEAA GTDITKYVFF
TPVVNNRTVF PDYTAKSLAG EVANVPTILG SNAQDGLAFV ILSTAVNQTE VFEATLDLFF
CPAFKAATNR LLASVPVFRY EYFGNFTDVS PLPFLGAYHG AELPLIFGTY DIFAETSTQS
PPPDKKLEVA TSRTIQNDWV AIAADGAAGL EERGWPLYSS VEEGLIRTYG VAAPVESTED
GWGAGGAGGI GGVPAGVADA RRIEALCPAI WQPAEVSE
//
