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Database: UniProt
Entry: Q7S9J4
LinkDB: Q7S9J4
Original site: Q7S9J4 
ID   DBP10_NEUCR             Reviewed;         934 AA.
AC   Q7S9J4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   16-OCT-2019, entry version 109.
DE   RecName: Full=ATP-dependent RNA helicase dbp-10;
DE            EC=3.6.4.13;
GN   Name=dbp-10; ORFNames=NCU07712;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC       subfamily. {ECO:0000305}.
DR   EMBL; CM002239; EAA33062.1; -; Genomic_DNA.
DR   RefSeq; XP_962298.1; XM_957205.2.
DR   SMR; Q7S9J4; -.
DR   PRIDE; Q7S9J4; -.
DR   EnsemblFungi; EAA33062; EAA33062; NCU07712.
DR   GeneID; 3878446; -.
DR   KEGG; ncr:NCU07712; -.
DR   EuPathDB; FungiDB:NCU07712; -.
DR   HOGENOM; HOG000246455; -.
DR   InParanoid; Q7S9J4; -.
DR   KO; K14808; -.
DR   OMA; CVEMDLK; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR012541; DBP10_C.
DR   InterPro; IPR033517; DDX54/DBP10.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR24031:SF292; PTHR24031:SF292; 1.
DR   Pfam; PF08147; DBP10CT; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM01123; DBP10CT; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    934       ATP-dependent RNA helicase dbp-10.
FT                                /FTId=PRO_0000232318.
FT   DOMAIN      130    302       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      359    513       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     143    150       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        99    127       Q motif.
FT   MOTIF       250    253       DEAD box.
SQ   SEQUENCE   934 AA;  103653 MW;  E010C55016EFAB98 CRC64;
     MPRRAASPTP SENEVDIAGA LFNNDSDFED NSSKHHTKKG AVTNSGLDLD FNDLLGNGDD
     GLPSFNGEGD DDEAFIASLT RSSQRKSSNI QGKSVKKGGG FQAMGLNAHL LRAITRKGFS
     VPTPIQRKAI PLILERKDVV GMARTGSGKT AAFVIPMIER LKGHSPRVGS RALIMSPSRE
     LALQTLKVVK ELGRGTDLKT VLLVGGDSLE EQFGMMASNP DIIIATPGRF LHLKVEMNLS
     LASIKYVVFD EADRLFEMGF ATELTEILHA LPPSRQTLLF SATLPSSLVE FARAGLQEPS
     LVRLDAETKV SPDLESAFFA VKGGEKEGAL LHLLHDVIKV PLGPPEGTKE ESDELQARKR
     KREYRPNPKE KPTEYSTIIF TATKHHVEYI ANLLKLAGFA VSYVYGSLDQ TARLIQVDNF
     RRGRTHILVV TDVAARGIDM PALANVINYD FPSQPKIFVH RVGRTARAGQ RGWAYGLVRQ
     SDVPYLLDLQ LFLGRKLIIG HDQKNPSFAA DVVVGTLKRD GVDVNIEWVE KALKESADLK
     ALKGVAAKAE KLYMKTRNSA SSQSAKRARE VTQSRGWTQL HPLFGEEAAE AQAARDDLLS
     RINRFKPQET IFELGPKGKS SRNKAAEVVR NMRSRFKERK TTNDEDDEDV DMEDAEGKPD
     GEETNAFEDF EDEEEEGEAE EAEEAEAKED PYADDSDSEM EVTVSSSMHT KKKGGPVNFQ
     DPEIFMSYTP RTTSLAEEKA YGVHSGGYSG NSFVEAARDA TMDLTNDESA KNFGLPTKSK
     MRWDKRHSKY VAVANDEDGS KGAKMIRGES GVKIAASFKS GRFDRWRKDN RLGKLPTIGE
     TEKSQLIRNF GAQPGQPRYK HKMEKAPKDA DKFRDDYHVR KKRVAEAKEK RIGKYKDGEG
     SKRELKTATD IRKARAVAEK KREKNARPAK RQKR
//
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