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Database: UniProt
Entry: Q7SBJ9
LinkDB: Q7SBJ9
Original site: Q7SBJ9 
ID   SET9_NEUCR              Reviewed;         777 AA.
AC   Q7SBJ9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   16-JAN-2019, entry version 90.
DE   RecName: Full=Histone-lysine N-methyltransferase set9;
DE            EC=2.1.1.43;
DE   AltName: Full=Histone-lysine methyltransferase 1;
DE   AltName: Full=SET domain protein 9;
GN   Name=hlm-1; Synonyms=set9; ORFNames=NCU08551;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; CM002238; EAA33797.2; -; Genomic_DNA.
DR   RefSeq; XP_963033.2; XM_957940.2.
DR   PRIDE; Q7SBJ9; -.
DR   EnsemblFungi; EAA33797; EAA33797; NCU08551.
DR   GeneID; 3879172; -.
DR   KEGG; ncr:NCU08551; -.
DR   EuPathDB; FungiDB:NCU08551; -.
DR   HOGENOM; HOG000214006; -.
DR   InParanoid; Q7SBJ9; -.
DR   KO; K11429; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    777       Histone-lysine N-methyltransferase set9.
FT                                /FTId=PRO_0000281805.
FT   DOMAIN      117    231       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   777 AA;  86094 MW;  F15745E5259F5AA0 CRC64;
     MTKPQGTGGK KKNQLTLAQL AAYDDILTDA LVDHAYYWTT IPKNRTSYHP SRGIKEEEIT
     KIIQNHLIVD PDIATAEEKL LATDGLKRFC NTLKTPREQN DFKAHLRRYM SIYLPDCPFE
     VNATNRYTIV TYEASITARR FIQRNETIKY LAGIQVVITP EEELEMSLRK KDFSLIVSSR
     SKSTSLFMGP ARFANHDCNA NARLITRGQA GIEIIACRNI EVGEEITVTY SESYFGENNC
     DCLCATCESN LRNGWRPVDG EAAVQKSIED EQPTESSTPY SFRRKRRYGS TALQASRTPS
     VTPDMRPRVL RKSQSQMMLG ERTSTTDSAA QGAGADGQSR KRALEMGTPP FTPTKKQKTT
     QYPVVPIALS TAPSRGSSDN ETSKSPLSFS TTNDNVTDAT SQGSESPGPI ILSPEPTPIK
     QAIGLLKQEE GVNEVAVQQV PEAFTPPPSQ PTEEEPPMVR PAFERLAARD RMSIANLISG
     PSSPAPPVVF SVAEVTTHRP KPQTLQLQKT DQTATISTLQ TVTAAVQKEA PVVKTESPIK
     PTVGQVEKIT QVQTTTKSCT PSKPKAQAAA LPQHHMPVST APRGRVPHDY TLTPLLLSEP
     ETAWIMCTHC ASAFVQKNAY LTKSTCPRCE RHSKLYGYMW PKTEKYGPND KEERILDHRM
     INRFLTAEEE ARARGRVYWR ERMGSKGKQG SSAPSTKGTP AGEKNEQSAK QEQSQGQYVQ
     ERFAVRKKVK VQVRSTVPTP VIMTKKDEVA EAAALGLRRS GRARRVSAKL ADCELDF
//
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