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Database: UniProt
Entry: Q7SDI0_NEUCR
LinkDB: Q7SDI0_NEUCR
Original site: Q7SDI0_NEUCR 
ID   Q7SDI0_NEUCR            Unreviewed;       810 AA.
AC   Q7SDI0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   24-JAN-2024, entry version 121.
DE   SubName: Full=Heat shock protein 78 {ECO:0000313|EMBL:EAA34819.1};
GN   Name=hsp78 {ECO:0000313|EMBL:EAA34819.1};
GN   ORFNames=NCU02630 {ECO:0000313|EMBL:EAA34819.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA34819.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA34819.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; CM002236; EAA34819.1; -; Genomic_DNA.
DR   RefSeq; XP_964055.1; XM_958962.3.
DR   AlphaFoldDB; Q7SDI0; -.
DR   SMR; Q7SDI0; -.
DR   STRING; 367110.Q7SDI0; -.
DR   PaxDb; 5141-EFNCRP00000002199; -.
DR   EnsemblFungi; EAA34819; EAA34819; NCU02630.
DR   GeneID; 3880204; -.
DR   KEGG; ncr:NCU02630; -.
DR   VEuPathDB; FungiDB:NCU02630; -.
DR   HOGENOM; CLU_005070_4_0_1; -.
DR   InParanoid; Q7SDI0; -.
DR   OrthoDB; 35211at2759; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IEA:EnsemblFungi.
DR   GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0050821; P:protein stabilization; IEA:EnsemblFungi.
DR   GO; GO:0043335; P:protein unfolding; IBA:GO_Central.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF176; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Stress response {ECO:0000313|EMBL:EAA34819.1}.
FT   DOMAIN          125..270
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          523..663
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          701..790
FT                   /note="Clp ATPase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01086"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          62..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          791..810
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          338..418
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   810 AA;  89936 MW;  7AF9620FD8CC7DEC CRC64;
     MQTRRQLLST ATRRISEASR ASLSRTTRQF PRAPALGVTV PALNATHLAS SLRLLPTIAT
     RSYANGRPRP PGGTHRMNLG GEDEKPALEQ YGIDLTAKAR EGKLDPVIGR AAEIQRTIQI
     LSRRTKNNPV LIGCAGVGKT AILEGLALEI VKGAVPESIK NRRVISLDLG SLIAGAKFRG
     DFEERLKKVL GEVQEANGEV ILFIDELHTL LGLGKAEGSI DASNLLKPAL SRGELQCCGA
     TTMTEYRQIE KDVALARRFQ PIIVSEPTVE DTISILRGIK EKYEVHHGVR ITDGALVAAA
     TYSNRYITDR FLPDKAIDLM DEAASSLRLQ QESKPDDIQR LDQKIMTIQI ELESLRKEKD
     VASVERREKL EADLKKYQDE VAVLTERWLK EKAEIDSIKQ TQAELDRARI ELEQAQRTGN
     FARASELRFG VIPNLEKKLP KDGERPTRDL SLIHDSVTAD DIANVVSRIT GIPISKLSSG
     HTERLIHMED ILRESVRGQD EALKAVADAV RMQRAGLSGE NRPLASFFFL GPTGVGKTEL
     CKKLAGFLFS TETAVVRFDM SEFQEKHTIS RLIGAPSGYV GYEDAGQLTE AVRRKPYAVI
     LLDEFEKAHR DISALLLQVL DEGYLTDAQG HKVDFKNTII VLTSNLGADI LVGANPMVPY
     KETEDGDIHP DVKQAVMDVV ASQYPPEFLN RIDSFIIFKR LAMEALRDIV DIRLKELQER
     LNDRRITLDV PEEVRQWLAE RGYDPKFGAR PLNRLITTEI GNGLADKIIR GQIKSGDKAV
     VEIKEDRSGL NVYAEQQEQP PAAEEAEAEA
//
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