ID Q7SEY6_NEUCR Unreviewed; 713 AA.
AC Q7SEY6;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=NCU02078 {ECO:0000313|EMBL:EAA35369.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA35369.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA35369.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CM002236; EAA35369.1; -; Genomic_DNA.
DR RefSeq; XP_964605.1; XM_959512.3.
DR AlphaFoldDB; Q7SEY6; -.
DR STRING; 367110.Q7SEY6; -.
DR PaxDb; 5141-EFNCRP00000001012; -.
DR EnsemblFungi; EAA35369; EAA35369; NCU02078.
DR GeneID; 3880745; -.
DR KEGG; ncr:NCU02078; -.
DR VEuPathDB; FungiDB:NCU02078; -.
DR HOGENOM; CLU_012767_0_0_1; -.
DR InParanoid; Q7SEY6; -.
DR OrthoDB; 2782399at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0016586; C:RSC-type complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04369; Bromodomain; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF26; -; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 65..135
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 312..386
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..235
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 78604 MW; 7790C5BD70C0E968 CRC64;
MDNKRKASIS NGAHIQNGDD RAAKRTKKEP GPYTDYDLNQ EETHESTTAY GLHFLEMIRR
TKDKSGRTVA DCFEDLIPRE GNEDYYRRIK LPISLKTIER KLHNQDFANL SELEGYFKRM
VMNAKEYYNK GSDIFEDAER VRKALSNYMT KTNPAYKRET GYSCTAAPIP GEEDDEESKN
ASQNGTKRHS SNSSTNGSVK SVRKRESPSV QDTQGEDDVE GEDDDHDDDR DESGDDDNEN
PRRIVIKRRE SGRPAARSTA SPVPMFKPGR GGRKKADHEY ENVPYKSLNF QQAQEKIVEE
LIRKPDGSDP YFLDFINLPP RSFKDYFAVI TEPLSLKGLQ KLVKGIYGRA SPTGVSEFKS
WAAFEEKASL LWNNAHYYNE EGSVIYDLAT ELKNCFEREL DQAKAVVQEP PQPPKIKLKV
APGSETPSVS GPKKITIHVG GSRGSAAASP APPTGQSIDS NYSHGAVNGN RVVPSAVPII
PQDKVRSLST SVVPSPAVTQ AKLEGGVQQS PVPLPPQAGV NGVAVGPGTL TPGINSQQAG
SAVFQNGHVP VVAPPPPPPI WDKIHRAPGR GLADALIHSI LIRTHPSIPL ERRFRLEVPA
HPRLAQQNLT VHLPTNHSRL QLIPRLSPIL EQQQRQYRLF ITINGSMVGR ATPLPIPDDP
LPVNAIVFDL PLQPGTTVIS VTMIAALPKG QKLPSGAECE LERISVNAFL PRV
//
