ID Q7SFM1_NEUCR Unreviewed; 876 AA.
AC Q7SFM1;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 111.
DE SubName: Full=Importin subunit beta-1 {ECO:0000313|EMBL:EAA35640.1};
GN ORFNames=NCU02011 {ECO:0000313|EMBL:EAA35640.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA35640.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA35640.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR EMBL; CM002236; EAA35640.1; -; Genomic_DNA.
DR RefSeq; XP_964876.1; XM_959783.3.
DR AlphaFoldDB; Q7SFM1; -.
DR STRING; 367110.Q7SFM1; -.
DR PaxDb; 5141-EFNCRP00000001032; -.
DR EnsemblFungi; EAA35640; EAA35640; NCU02011.
DR GeneID; 3881025; -.
DR KEGG; ncr:NCU02011; -.
DR VEuPathDB; FungiDB:NCU02011; -.
DR HOGENOM; CLU_008296_1_0_1; -.
DR InParanoid; Q7SFM1; -.
DR OrthoDB; 124901at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:1990023; C:mitotic spindle midzone; IEA:EnsemblFungi.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:EnsemblFungi.
DR GO; GO:0005635; C:nuclear envelope; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0097718; F:disordered domain specific binding; IEA:EnsemblFungi.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR GO; GO:0061676; F:importin-alpha family protein binding; IEA:EnsemblFungi.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IEA:EnsemblFungi.
DR GO; GO:0051292; P:nuclear pore complex assembly; IEA:EnsemblFungi.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IEA:EnsemblFungi.
DR GO; GO:0046822; P:regulation of nucleocytoplasmic transport; IEA:EnsemblFungi.
DR GO; GO:0060188; P:regulation of protein desumoylation; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00185; ARM; 2.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 25..106
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 876 AA; 96322 MW; 197D562B995F9885 CRC64;
MEGSSDINTV LTNSLSPDAT LRHAAEQQLS QAAQTNFSQY LVTLVQELAN ESAQSHIRAA
AGIALKNAFS AREFARQAEL QAKWLQQTDQ DTKTRVKQLT LETLASSSTQ ASQASAQVIA
AIATIELPRN EWPDLMHALV KNVSEGSEHQ KQASLTTIGF ICESQDVDLR NSLVQHSNAI
LTAVVQGARK EEPNREVRLA AITALGDSLE FVGNNFKHEG ERNYIMQVIC EATQAEDSRI
QQGAYGCLNR IMALYYENMR FYMEKALFGL TILGMKSDDE DVAKLAVEFW STVCEEEIAI
EDDNAQVESS EQMRPFYNFA RVATLEVVPV LLQLLTKQDE DAADDEYNIS RAAYQCLQLY
SQAVGAAIIQ PVIQFVEANL RADDWHLRDA AVSAFGAMMD GPEEKLLEPI VKSGMQPLIG
MMEDPSLHVR DSTAYALGRI TETCSEVIDP AVHLDPLITS LFNGLMSSPR MAASCCWALM
NLAERFGGEY GAAQNPITPH FNQCVTNLLA VTAKLDGDAT VRTAAYEVLN VFVQNAANDS
LPAVASLSDV ILQRLEETLP LQSQVVSVED KITLEDMQTS LCTVLQAIIQ RLDKEITPQG
DRIMQVLLQL LNTINGKSAV PEGVFAAISG LANAMEEDFA KYMDAFAPFL YNALANQEEP
SLCSMAIGLV SDITRSMGER SQPYCDQFMN YLLNNLRSTA LANQFKPAIL QCFGDIAGAI
GGHFEAYLSV VAVVLQQAAT VTASAEGSYE MFDYVISLRE GIMDAWGGII GAMKGSDKTN
VLEPYVQSIF ELLNTIAQDP NRSEALMRAA MGVIGDLADA YPNGQLAEVF RQDWITAMIK
ETRSNREFQQ RTIETARWAR EQVKRQISGT QGMIQT
//