ID Q7SGQ9_NEUCR Unreviewed; 573 AA.
AC Q7SGQ9;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Acetamidase {ECO:0000313|EMBL:EAA36023.1};
GN ORFNames=NCU08356 {ECO:0000313|EMBL:EAA36023.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA36023.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA36023.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002236; EAA36023.1; -; Genomic_DNA.
DR RefSeq; XP_965259.1; XM_960166.2.
DR AlphaFoldDB; Q7SGQ9; -.
DR STRING; 367110.Q7SGQ9; -.
DR PaxDb; 5141-EFNCRP00000006424; -.
DR EnsemblFungi; EAA36023; EAA36023; NCU08356.
DR GeneID; 3881399; -.
DR KEGG; ncr:NCU08356; -.
DR VEuPathDB; FungiDB:NCU08356; -.
DR HOGENOM; CLU_009600_9_3_1; -.
DR InParanoid; Q7SGQ9; -.
DR OMA; GMQPWKY; -.
DR OrthoDB; 731186at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 1.
DR InterPro; IPR023631; Amidase_dom.
DR InterPro; IPR036928; AS_sf.
DR PANTHER; PTHR46072:SF10; ACETAMIDASE; 1.
DR PANTHER; PTHR46072; AMIDASE-RELATED-RELATED; 1.
DR Pfam; PF01425; Amidase; 1.
DR PIRSF; PIRSF001221; Amidase_fungi; 1.
DR SUPFAM; SSF75304; Amidase signature (AS) enzymes; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT DOMAIN 65..545
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
FT ACT_SITE 115
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-1"
FT ACT_SITE 192
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-1"
FT ACT_SITE 215
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-1"
FT BINDING 166
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-2"
FT BINDING 192
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-2"
FT BINDING 212..215
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001221-2"
SQ SEQUENCE 573 AA; 64089 MW; 2BF65CD78F510DF7 CRC64;
MSFLSDYLRH KRDCNLKRAE RKERISSLGP EYHAALSGKD LDTINKPIAE LVSGVQSNAI
SPLSVLQTYG KVAIRAHLKT NCLTEVLISA AEDSLKNSKR VNLQGPLAGI PVSLKDTIIV
GGFDTTVGYS SFVGNKADNP QDGPMVRLLK DAGAVPYVKT NLPISLLSYE STNDVWGRCT
NPHNKAYSPG GSTGGESALL ACGGRIGIGS DVAGSVRVPA HFSGCYSLRC ATGRWPKAGI
LTSMPGQEGV PSVYSPMART LDDLSYFTKA VIGMKPWKYD HSVHPLAWRD EVVEEFTDQE
RRLRVGVLRT DKVVDPSPAC KRALETVEEA LRREGHEIVE MEDAPDMFEA LRMGALLLNA
DGGWWFNSYR RFGEWLDSGA SLLSFGKWPS IVRYLSYMWI KYIRRDNLWA ELVKQTRPIS
AAENWGEVKK REAYRAEWFE YWNRKQFDVL ISPPNALPAI PHDASKDTFS NCGYCFLFNL
LDYTAGIIPV THVDSALDKL PSTFDHKRLN GIATRAYRHY DAERMHGLPV GVQIIGRRLE
EEKVLAVMKR VENALREDRY KLFDPELLNN VVD
//
