ID Q7SHC3_NEUCR Unreviewed; 525 AA.
AC Q7SHC3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 110.
DE SubName: Full=SH3 domain signaling protein {ECO:0000313|EMBL:EAA36278.1};
GN ORFNames=NCU01883 {ECO:0000313|EMBL:EAA36278.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA36278.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA36278.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002236; EAA36278.1; -; Genomic_DNA.
DR RefSeq; XP_965514.1; XM_960421.2.
DR AlphaFoldDB; Q7SHC3; -.
DR STRING; 367110.Q7SHC3; -.
DR PaxDb; 5141-EFNCRP00000001197; -.
DR EnsemblFungi; EAA36278; EAA36278; NCU01883.
DR GeneID; 3881692; -.
DR KEGG; ncr:NCU01883; -.
DR VEuPathDB; FungiDB:NCU01883; -.
DR HOGENOM; CLU_025518_1_0_1; -.
DR InParanoid; Q7SHC3; -.
DR OrthoDB; 2972088at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0030479; C:actin cortical patch; IBA:GO_Central.
DR GO; GO:0043332; C:mating projection tip; IBA:GO_Central.
DR GO; GO:0031097; C:medial cortex; IBA:GO_Central.
DR GO; GO:1990528; C:Rvs161p-Rvs167p complex; IBA:GO_Central.
DR GO; GO:0051666; P:actin cortical patch localization; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR CDD; cd07599; BAR_Rvs167p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR046982; BIN3/RVS161-like.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47174; BRIDGING INTEGRATOR 3; 1.
DR PANTHER; PTHR47174:SF2; SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670); 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 7..241
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 466..525
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 278..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 132..159
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 303..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 57065 MW; 30817BA0DB9CA66F CRC64;
MQSVQRQFTK LRSKGPGNNA AVSVLLKEYE DADQLLARLL ENSRAWKDAW ASIVHHQLQF
VVELEGLYDP IVGASDGHGR ESVPTPRLQL ERTYRLKQAF GELKSELAEE IGTIEDRVIR
PAVEARDCIA PIRKTIKKRE NKRLDYERAQ DKVSKLHKKH TRTPKEEASL AKAEVEMAQA
GDEFAIADEH LQSTLPPIIN ASFSLVPSLV AALVLIQNRL LGLYYTTIHG YCMESGFPSP
PPPMSDVVAA WEAAFVPARD DFESVSIVAR GKAAHSPMAL QAPEGPGRRI SAIIPGRNDM
RRVTSPMPST SGAASTYSSG ASQPGRNNLR IPSAGGYPSR APSPAASDRS SYASSPPASS
YSGYSGSQNQ QRRPDYLAPT DFTAATALGD RGSVDRGTIE NNRPFPRSPS TTAPSINRVH
SPQATRNAGS ANGNGNGNGN DYFALAVAKK RPPPPPPPKR ITSQQQLVEY VVAQYTFAGQ
GAGDLAFNEG DKIKIIKKTN TDQDWWVGEL NGKRGNFPAN YCKPV
//
