ID Q7SHW3_NEUCR Unreviewed; 794 AA.
AC Q7SHW3;
DT 15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=IBR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NCU00691 {ECO:0000313|EMBL:EAA36595.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA36595.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA36595.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
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DR EMBL; CM002236; EAA36595.1; -; Genomic_DNA.
DR RefSeq; XP_965831.1; XM_960738.2.
DR AlphaFoldDB; Q7SHW3; -.
DR PaxDb; 5141-EFNCRP00000000726; -.
DR EnsemblFungi; EAA36595; EAA36595; NCU00691.
DR GeneID; 3881893; -.
DR KEGG; ncr:NCU00691; -.
DR VEuPathDB; FungiDB:NCU00691; -.
DR HOGENOM; CLU_025203_1_0_1; -.
DR InParanoid; Q7SHW3; -.
DR OrthoDB; 2725066at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd22584; Rcat_RBR_unk; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR11685:SF457; TRANSLATION TERMINATION INHIBITOR PROTEIN ITT1; 1.
DR Pfam; PF01485; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 203..406
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 207..253
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 95..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 479..506
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 604..635
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 735..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 90254 MW; 2B1D2C30C13E0518 CRC64;
MAESTSVSLS SAHLVGTVAN PPKLDESEYL REVFGITTED ATATEAEIEE SLTAKASSLG
IDVSNLTDSL GNPTALNATS ARSSTLVAHQ RSNTICSNDS TTGTETATGT DNDMASNSSA
AMPATLTQST SRKRSNTVNF SQYEKYLTQL KPALHQPKFS NPAAPTRRPS HNIFGFGHFK
GVRELRRGLT GRLKRRKTYP ALPIVICICC REEFAQENHL LQTLPCGHTY CQNCLAVMIN
QSTTDESKMP PRCCTQPIPS SIIKTILTRE EQQAFLKAVL QYSTPWESRI FCPNPACGEF
IPPRAKLDPK HPFETMCKTC KMRVCLICKR SAHRLGQDCP EDIELETVLK MGEKSGWRRC
YKCRNLVELT QGCTHMTCRC KAQFCYICGA VWDPVVGCPN FCNGEEELER RRREEETRLA
ELEVKKREQE EAAAAEGRAQ QAAERRTRDS VEFQALRERQ NHEMSRVLAY EARMRKDMRT
KQSEKKKALL EKYAELTEKM KERHAKTEQH LEDRQIEAEM ELRSSLDASE RSIKIQLKHM
EAYCKTLSQV EEVSEKDQAL QDSKMPSREV TQKHLDQLSE QYRIRDGMER RHQAQINVLR
EKQGKKMEQL LDRHEDEMEA LLHKKSEELE DLAVEFANEA DAVSRTFAQR KVKLQKRWLV
SVEILRVEQE KKTGMRYASM AVPQWPAATT TESDTETESE EEETTAAAHL QEQEVIELAR
PKAEAEMKED GWPLSNNDNI KTTEIELPST PKTVTPAVTP TQARFEAELR RYRSRTRLVA
PGEQSPPVSP RTMR
//
