ID G6PT3_DANRE Reviewed; 494 AA.
AC Q7SY29; Q4V952;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Glucose-6-phosphate exchanger SLC37A2 {ECO:0000305};
DE AltName: Full=Solute carrier family 37 member 2 {ECO:0000250|UniProtKB:Q8TED4};
GN Name=slc37a2 {ECO:0000250|UniProtKB:Q8TED4};
GN ORFNames=zgc:63583 {ECO:0000312|EMBL:AAH55147.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inorganic phosphate and glucose-6-phosphate antiporter. May
CC transport cytoplasmic glucose-6-phosphate into the lumen of the
CC endoplasmic reticulum and translocate inorganic phosphate into the
CC opposite direction. {ECO:0000250|UniProtKB:Q8TED4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-
CC phosphate(out) + phosphate(in); Xref=Rhea:RHEA:71535,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:61548;
CC Evidence={ECO:0000250|UniProtKB:Q8TED4};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8TED4}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7SY29-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7SY29-2; Sequence=VSP_028965;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; BC055147; AAH55147.1; -; mRNA.
DR EMBL; BC097056; AAH97056.1; -; mRNA.
DR RefSeq; NP_998179.1; NM_213014.1.
DR AlphaFoldDB; Q7SY29; -.
DR SMR; Q7SY29; -.
DR STRING; 7955.ENSDARP00000038646; -.
DR GlyCosmos; Q7SY29; 3 sites, No reported glycans.
DR PaxDb; 7955-ENSDARP00000038646; -.
DR GeneID; 406287; -.
DR KEGG; dre:406287; -.
DR AGR; ZFIN:ZDB-GENE-040426-1949; -.
DR CTD; 219855; -.
DR ZFIN; ZDB-GENE-040426-1949; slc37a2.
DR eggNOG; KOG2533; Eukaryota.
DR InParanoid; Q7SY29; -.
DR OrthoDB; 69287at2759; -.
DR PhylomeDB; Q7SY29; -.
DR Reactome; R-DRE-70263; Gluconeogenesis.
DR PRO; PR:Q7SY29; -.
DR Proteomes; UP000000437; Chromosome 5.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0061513; F:glucose 6-phosphate:inorganic phosphate antiporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0015760; P:glucose-6-phosphate transport; ISS:UniProtKB.
DR GO; GO:0090382; P:phagosome maturation; IMP:ZFIN.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; ISS:UniProtKB.
DR CDD; cd17344; MFS_SLC37A1_2; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044740; SLC37A1_2.
DR InterPro; IPR000849; Sugar_P_transporter.
DR PANTHER; PTHR43184:SF9; GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A2; 1.
DR PANTHER; PTHR43184; MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Endoplasmic reticulum; Glycoprotein;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..494
FT /note="Glucose-6-phosphate exchanger SLC37A2"
FT /id="PRO_0000308324"
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 491..494
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028965"
FT CONFLICT 381
FT /note="P -> L (in Ref. 1; AAH97056)"
FT /evidence="ECO:0000305"
FT CONFLICT 414
FT /note="C -> S (in Ref. 1; AAH97056)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 54040 MW; F583EBEC623864EB CRC64;
MKSLAPGIKL ITSFSRDSWY RFSILFLTFV FYTSYHLSRK PISIVKSQLH RNCSNVVHPA
NLNITDNDTW CDWVPFDGKN YQNLFGVLDN CFLVAYAVGM FFSGIFGERL PLRYYLSTGM
LLSGLFTALF GLGFYWQIHS LWYYCLVQAL NGLVQTTGWP AVVACVGNWF GKGKRGFIMG
VWNSHTSVGN ILGSLIAGVY VSSAWGLSFI VPGIIIASTG VICFLFLVER PEDVNCTAPQ
HHERVEEEPL LRNSSTNEEI FNSHTSTAVE PVEDHSEAIS FCGALRIPGV VEFSLCLLFA
KLVSYTFLYW LPLYIANVAH FDPKKAGDLS TLFDVGGILG GIVAGLVSDY TGGRASTCCA
MLIIAAPMLF LYNKIGQNGL PTTVGMLLWC GALVNGPYAL ITTAVSADLG THECLRGNSR
ALSTVTAIID GTGSIGAAVG PLLAGLISPT GWNNVFYMLI AADVLACLLL SRLVYKEIRG
WCGYTTRQRG FKEI
//
